检验医学与临床2026，Vol.23Issue(10)：1334-1339,6.DOI:10.3969/j.issn.1672-9455.2026.10.006
胃充盈超声造影联合血清DDIT4、LTBP2对早期胃癌的诊断价值
Diagnostic value of gastric filling contrast-enhanced ultrasound combined with serum DDIT4 and LTBP2 in early gastric cancer
摘要
Abstract
Objective To explore the diagnostic value of gastric filling contrast-enhanced ultrasound com-bined with serum DNA damage-inducible transcript 4(DDIT4)and latent transforming growth factor beta binding protein 2(LTBP2)in early gastric cancer.Methods A total of 120 high-risk patients with gastric cancer admitted and treated in this hospital from October 2023 to June 2024 were selected as the research sub-jects.All selected subjects were followed up for 12 months and during the follow up period the multiple rounds of gastric filling contrast-enhanced ultrasound and pathological examinations were conducted.They were classified into the patients with gastric cancer and the patients with non-gastric cancer based on the diag-nosis.The serum DDIT4 and LTBP2 levels were detected by the enzyme-linked immunosorbent assay.The re-ceiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficiency of serum DDIT4 and LTBP2 for gastric cancer and the optimal cut-off values were obtained.The pathological examination re-sults were taken as the gold standard,and the diagnostic efficiency of gastric filling contrast-enhanced ultra-sound and serum DDIT4 and LTBP2 detection for gastric cancer was analyzed through the diagnostic fourfold table.Results The pathological examination results showed that among the 120 high-risk patients with gas-tric cancer,there were 64 cases of gastric cancer and 56 cases of non-gastric cancer.The serum DDIT4 and LT-BP2 levels in the patients with gastric cancer were significantly higher than those in the patients with non-gas-tric cancer(P<0.05).The serum DDIT4 and LTBP2 levels in gastric cancer patients with a maximum tumor diameter≥2 cm were higher than those with a maximum tumor diameter<2 cm(P<0.05),the serum DDIT4 and LTBP2 levels in gastric cancer patients with TNM stage Ⅰ were higher than those with stage 0(P<0.05),the serum DDIT4 and LTBP2 levels in gastric cancer patients with low differentiaton were higher than those with moderately to high differentiation(P<0.05).The optimal cut-off values of serum DDIT4 and LTBP2 for diagnosing gastric cancer were 9.787 ng/L and 19.891 μg/L,respectively.The accuracy degree of gastric filling contrast-enhanced ultrasound in diagnosing gastric cancer was 75.83%,which of serum DDIT4 in diagnosing early gastric cancer was 79.17%,and which of serum LTBP2 in diagnosing early gastric cancer was 73.33%.The sensitivity,specificity,accuracy,negative predictive value and positive predictive value of gastric filling contrast-enhanced ultrasound combined with serum DDIT4 and LTBP2 detection in diagnosing gastric cancer were 90.63%,91.07%,90.83%,89.47%and 92.06%,respectively.The accuracy of the 3-item combination diagnosis for gastric cancer was higher than that of any single indicator(P<0.05).Conclusion The serum DDIT4 and LTBP2 levels in the patients with early gastric cancer are increased and related to some clin-ical pathological features.The combination of gastric filling contrast-enhanced ultrasound with serum DDIT4 and LTBP2 detection has a high diagnostic value for early gastric cancer and is a promising early diagnostic method for gastric cancer in high-risk patients.关键词
胃癌/胃充盈超声造影/DNA损伤诱导转录因子4/转化生长因子结合蛋白2/诊断Key words
gastric cancer/gastric filling contrast-enhanced ultrasound/DNA damage-inducible tran-script 4/latent transforming growth factor-β binding protein 2/diagnosis分类
医药卫生引用本文复制引用
许万,罗伊真,刘治,胡婧,赵世恩..胃充盈超声造影联合血清DDIT4、LTBP2对早期胃癌的诊断价值[J].检验医学与临床,2026,23(10):1334-1339,6.基金项目
甘肃省高校教师创新基金项目(2025A-187). （2025A-187）
