检验医学与临床2026，Vol.23Issue(10)：1365-1370,6.DOI:10.3969/j.issn.1672-9455.2026.10.010
NLR、PLR和SII对三阴性乳腺癌患者根治术后复发转移的预测价值
Predictive value of NLR,PLR and SII for recurrence and metastasis after radical surgery in patients with triple-negative breast cancer
摘要
Abstract
Objective To investigate the predictive value of inflammatory composite indicators[neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic immune-inflammation index(SII)]for postoperative recurrence and metastasis in the patients with triple-negative breast cancer(TNBC).Meth-ods A total of 170 female TNBC patients admitted and treated in Jiamusi Municipal Central Hospital from January 2022 to March 2024 were selected as the study subjects.The postoperative follow-up was conducted through outpatient reexamination for 2 years.According to whether the recurrence or metastasis occurred dur-ing the follow-up period,the patients were divided into the recurrence and metastasis group(recurrence or me-tastasis occurrence)and non-recurrence and metastasis group(without recurrence or metastasis occurrence).The baseline data of the patients were collected and compared.The neutrophil count,lymphocyte count and platelet count were detected before operation.The NLR,PLR and SII were calculated.The Cox regression was used to analyze the influencing factors of the recurrence and metastasis after radical surgery in TNBC pa-tients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficiency of the NLR,PLR and SII for the recurrence and metastasis after radical surgery in TNBC patients.Results There were 53 cases in the recurrence and metastasis group and 117 cases in the non-recurrence and metastasis group.The proportions of NLR,PLR,SII and TNM stage Ⅲ,and lymph node metastasis in the recurrence and metastasis group were all higher than those in the non-recurrence and metastasis group(P<0.001).The Cox regression analysis results showed that the TNM stage Ⅲ,lymph node metastasis and increased NLR,PLR and SII all were the risk factors for recurrence and metastasis after radical surgery in TNBC patients(P<0.05).The ROC curve analysis results showed that the areas under curves(AUCs)of NLR,PLR and SII alone and 3-item combination for predicting recurrence and metastasis after radical operation in TNBC patients were 0.694,0.722,0.735 and 0.847,respectively,the AUC of the 3-item combination prediction was greater than that of NLR,PLR SII alone(Z=2.952,2.623,1.969;P<0.05).Conclusion The increased NLR,PLR and SII are the risk factors for recurrence and metastasis after radical surgery in TNBC patients,and the 3-item combina-tion has a higher predictive value for recurrence and metastasis after radical surgery in TNBC patients.关键词
三阴性乳腺癌/中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值/系统性免疫炎症指数/复发转移/预测Key words
triple-negative breast cancer/neutrophil-to-lymphocyte ratio/platelet-to-lymphocyte rati-o/systemic immune inflammation index/recurrence and metastasis/prediction分类
医药卫生引用本文复制引用
丁典,李冠林,廉奇鑫..NLR、PLR和SII对三阴性乳腺癌患者根治术后复发转移的预测价值[J].检验医学与临床,2026,23(10):1365-1370,6.基金项目
黑龙江省卫生健康委科研课题(20230404080178). （20230404080178）
