兰州大学学报（医学版）2026，Vol.52Issue(3)：24-31,8.DOI:10.13885/j.issn.2097-681X.M20250230
NF-κB信号通路在低分子量多环芳烃致肺部炎症中的作用机制研究
Mechanism behind of the action of NF-κB signaling pathway in pulmonary inflammation caused by low molecular weight polycyclic aromatic hydrocarbons
摘要
Abstract
Objective To investigate the mechanism by which low molecular weight polycyclic aromatic hydrocarbons(LMW-PAHs)induce pulmonary inflammatory injury through the activation of the nuclear fac-tor kappa-B(NF-κB)/phosphorylation nuclear factor κB(p-NF-κB)signaling pathway via oxidative stress.Methods An LMW-PAHs-exposed animal model was established.Pathological changes in rat lung tissue were observed.Protein expression levels of pulmonary inflammatory mediators interleukin-1β(IL-1β)and IL-4 were detected.The oxidative stress markers glutathione peroxidase(GSH-PX)and total antioxidant capacity(T-AOC),and the expression levels of NF-κ B signaling pathway proteins were observed to investigate the mechanisms by which LMW-PAHs induce pulmonary inflammation.Results Compared with the control group,all exposed groups showed decreased T-AOC concentration and GSH-PX activity(P<0.05);NF-κB/p-NF-κB protein activity was significantly elevated(P<0.05);IL-1β levels were significantly increased in the high-dose group(P<0.05);IL-4 levels were significantly reduced across all dose groups(P<0.05).Conclusion LMW-PAHs induce oxidative stress,thereby activating the NF-κB signaling pathway to promote inflammatory cytokine release,thus resulting in inflammatory lung injury.关键词
低分子量多环芳烃/炎症/氧化应激/核因子κB信号通路/磷酸化核因子κB信号通路/肺炎/机制Key words
low molecular weight polycyclic aromatic hydrocarbons/inflammation/oxidative stress/nuclear factor kappa-B signaling pathway/phosphorylation nuclear factor κB signaling pathway/pulmonary inflam-mation/mechanism分类
医药卫生引用本文复制引用
胡旖轩,唐祯强,罗丹,张驰,覃家莉,李元杰,李云婷,马海涛,王俊玲..NF-κB信号通路在低分子量多环芳烃致肺部炎症中的作用机制研究[J].兰州大学学报（医学版）,2026,52(3):24-31,8.基金项目
中央高校项目"青稞计划"资助项目(lzujbky-2024-it67,lzujbky-2024-it21) （lzujbky-2024-it67,lzujbky-2024-it21）
甘肃省科技重点研发计划资助项目(25YF-FA028) （25YF-FA028）
2025年国家级大学生创新创业训练计划资助项目(20250080023) （20250080023）
