兰州大学学报（医学版）2026，Vol.52Issue(3)：32-37,6.DOI:10.13885/j.issn.2097-681X.M20260426
短期高海拔暴露对世居海平面青年脉络膜循环的影响
Effects of short-term high-altitude exposure on choroidal circulation in young adult sea-level residents
摘要
Abstract
Objective To investigate the effects of short-term high-altitude exposure on choroidal blood flow in healthy adults residing at sea level.Methods This prospective observational study included 9 healthy sea level-residing volunteers.Optical coherence tomography angiography was performed at eight time points:baseline at sea level,on days 2,4,7,and 10 of high-altitude exposure,and on days 3,5,and 9 after returning to sea level.Bilateral choroidal parameters,including choroidal thickness,choroidal stromal volume,choroi-dal vascular volume,choroidal vascularity index,and choriocapillaris flow density,were quantitatively ana-lyzed.Linear mixed-effects models were employed for statistical analysis.Results Choroidal stromal volume was significantly elevated on day 2 of high-altitude exposure(P<0.05),peaked on day 10,and decreased by day 3 after returning to sea level,showing no significant difference from baseline.choroidal vascular volume and choroidal vascularity index decreased significantly from day 2 of exposure(P<0.05),remained at this reduced level on days 4,7,and 10 with no difference from day 2,and returned to baseline levels by day 3 after returning to sea level(P>0.05).choriocapillaris flow density exhibited a transient significant increase only on day 3 of exposure(P<0.05),with no significant difference at other time points compared to baseline.Mean choroidal thickness showed no significant changes throughout the exposure and post-return periods.Conclusion Short-term high-altitude exposure induces alterations in choroidal blood flow in healthy sea lev-el-residing adults,which are reversible upon descent to sea level.关键词
高海拔/脉络膜/脉络膜厚度/脉络膜基质体积/脉络膜血管体积/脉络膜血管指数/脉络膜毛细血管血流密度Key words
high altitude/choroid/choroidal thickness/choroidal stromal volume/choroidal vascular volume/choroidal vascularity index/choriocapillaris flow density分类
医药卫生引用本文复制引用
邹卉盈,张艺凡,周旭,彭怡,邵彦..短期高海拔暴露对世居海平面青年脉络膜循环的影响[J].兰州大学学报（医学版）,2026,52(3):32-37,6.基金项目
国家自然科学基金区域科学专项基金资助项目(82360209) （82360209）
