临床与实验病理学杂志2026，Vol.42Issue(4)：421-425,5.DOI:10.13315/j.cnki.cjcep.2026.04.001
间质性肺疾病病理诊断模式的更新与思考
Update and reflection on the pathological diagnostic paradigm of interstitial lung diseases
摘要
Abstract
Interstitial lung disease(ILD)comprises a group of highly heterogeneous non-neoplastic disorders,and its pathological diagnosis has long remained a major challenge in both clinical practice and pathology.With the widespread application of minimally invasive techniques such as transbronchial cryobiopsy,the 2025 update of the in-ternational multidisciplinary classification of interstitial pneumonias,and the emergence of new technologies including artificial intelligence(AI),the pathological diagnostic paradigm for ILD is undergoing profound transformation.This article aims to analyze the current status and key bottlenecks of pathological diagnosis of ILD in China,discuss the in-sights provided by the updated classification system,reaffirm the cornerstone role of clinico-radiologic-pathologic mul-tidisciplinary diagnosis,and explore the potential of emerging technologies in improving diagnostic performance.Ulti-mately,an integrative strategy is proposed to address current challenges and to facilitate the transition of ILD diagnosis and management from reliance on a single pathological pattern toward a dynamic,precise,and integrated diagnostic and management paradigm.关键词
间质性肺疾病/诊断模式/人工智能/基因分析Key words
interstitial lung disease/diagnostic paradigm/artificial intelligence/genomic analysis分类
医药卫生引用本文复制引用
易祥华,顾莹莹..间质性肺疾病病理诊断模式的更新与思考[J].临床与实验病理学杂志,2026,42(4):421-425,5.基金项目
国家自然科学基金(82170082)、上海市科学技术委员会医学重点科技攻关专项基金(09411951600)、上海市科学技术委员会医学引导类项目基金(19411964700) National Natural Science Foundation of China(82170082) （82170082）
The Medical Key Scientific Research Project of the Shanghai Municipal Science and Technology Commission(09411951600) （09411951600）
The Medical Guidance Proj-ect of the Shanghai Municipal Science and Technology Commission(19411964700) （19411964700）
