中国临床保健杂志2026，Vol.29Issue(2)：172-179,8.DOI:10.3969/J.issn.1672-6790.2026.02.006
细胞外囊泡在腹主动脉瘤中的作用机制研究进展
Progress in the study of the mechanisms of extracellular vesicles in abdominal aortic aneurysm
摘要
Abstract
Abdominal aortic aneurysm(AAA)is a vascular disease characterized by focal dilation of the abdominal aorta and a high risk of rupture-related mortality.Its development involves multiple pathological processes,including inflammatory cell infiltration,vascular smooth muscle cell(VSMC)apoptosis and phenotypic modulation,endothelial dysfunction,and extracellular matrix(ECM)degradation and remodeling.In recent years,extracellular vesicles(EV)have gained increasing attention as essential mediators of intercellular communication.EV can stably transport non-coding RNAs such as miRNAs and lncRNAs,as well as diverse proteins,thereby actively participating in AAA initiation and progression by regulating immune responses,VSMC phenotypic switching,and vascular wall remodeling.Accumulating evidences have demonstrated distinct mechanisms of EV derived from different cell types in AAA,and circulating EV-associated miRNAs have shown potential as liquid biopsy biomarkers.Moreover,mesenchymal stem cell-derived EV(MSC-EV)and engineered EV exhibit promising anti-inflammatory,anti-apoptotic,and vascular-repair effects in experimental AAA models.This review summarizes the roles of extracellular vesicles in the pathogenesis and progression of AAA and highlights recent mechanistic advances,aiming to provide scientific insights and reference directions for future research at the intersection of EV biology and AAA.关键词
主动脉瘤,腹/细胞外囊泡/微RNAs/炎症/血管重塑Key words
Aortic aneurysm,abdominal/Extracellular vesicles/MicroRNAs/Inflammation/Vascular remodeling引用本文复制引用
张涛,梁量量,赵敬凯,郭宇明,刘梓琪,徐义岩,王海洋..细胞外囊泡在腹主动脉瘤中的作用机制研究进展[J].中国临床保健杂志,2026,29(2):172-179,8.基金项目
国家自然科学基金项目(82170501) National Natural Science Foundation of China(82170501) （82170501）
