中国临床保健杂志2026，Vol.29Issue(2)：195-199,5.DOI:10.3969/J.issn.1672-6790.2026.02.010
不同血栓清除方式治疗下肢深静脉血栓的效果对比
Comparative analysis of the efficacy of different thrombus removal modalities in the treatment of lower extremity deep vein thrombosis
摘要
Abstract
Objective To explore the differences in efficacy and safety among anticoagulation(AC),catheter-directed thrombolysis(CDT),and percutaneous mechanical thrombectomy(PMT)in the treatment of deep venous thrombosis(DVT)in the lower extremities.Methods A retrospective analysis was conducted on the clinical data of 90 patients with acute DVT in the lower extremities diagnosed and treated in the First Affiliated Hospital of University of Science and Technology of China from January 2022 to January 2025.Patients were divided into three groups based on their treatment regimens:AC group(n=30),CDT group(n=30),PMT group(n=30).The baseline characteristics,early efficacy(thrombus clearance rate,limb circumference difference),and long-term efficacy(venous patency score,Villalta score)were compared among the three groups.Results There were no significant differences in baseline characteristics among the three groups(P＞0.05).In terms of early thrombus clearance rate and limb swelling regression,both the PMT group and the CDT group showed superior to the AC group(both P＜0.05).Follow-up at 12 months after surgery showed that the long-term efficacy of the PMT group was superior to that of the CDT group and the AC group,with a no statistically significant difference between the CDT group and the AC group(P＞0.05).Subgroup analysis further revealed that the stent group had a lower venous patency score and Villalta score at 12 months compared to the non-stent group;the CDT+stent group had a lower venous patency rate and Villalta score at 12 months compared to the AC group(P＜0.05).Conclusions For acute DVT in the lower extremities,especially for central or mixed type DVT,aggressive interventional therapy(CDT or PMT)combined with iliac vein stent implantation can more effectively clear thrombus,maintain long-term venous patency,and reduce the incidence of post-thrombotic syndrome.Although anticoagulation therapy alone has a high incidence of post-thrombotic syndrome,it remains a safe and irreplaceable basic treatment for patients with peripheral DVT,elderly patients,those at high risk of bleeding,or those unable to undergo interventional therapy.关键词
下肢深静脉血栓/血栓切除术/支架/纤维蛋白溶解药Key words
Lower extremity deep vein thrombosis/Thrombectomy/Stent/Fibrinolytic agents引用本文复制引用
洪磊,王晓天,沈涛,谢峦,方征东,孙小杰,胡何节,葛新宝,程灿,沈广辉..不同血栓清除方式治疗下肢深静脉血栓的效果对比[J].中国临床保健杂志,2026,29(2):195-199,5.基金项目
安徽省自然科学基金项目(2208085MH199) Natural Science Foundation of Anhui Province(2208085MH199) （2208085MH199）
