皮肤性病诊疗学杂志2026，Vol.33Issue(4)：262-270,9.DOI:10.3969/j.issn.1674-8468.2026.04.003
自拟中药复方联合火针放血治疗囊肿型痤疮的临床疗效
Clinical study on the efficacy of self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting in the treatment of cystic acne
摘要
Abstract
Objective To evaluate the clinical efficacy of self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting in treating cystic acne.Methods Eighty patients with cystic acne admitted to our hospital from January 2023 to March 2025 were enrolled and randomly divided into a control group(n=40)and an observation group(n=40).The control group was treated with oral isotretinoin capsules combined with fire needle bloodletting therapy,while the observation group received the self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting therapy.The total clinical ef-fective rates,skin lesion scores,Dermatology life quality index scores,serum inflammatory factor levels(TNF-α,CRP,IL-6,IL-1β),and facial sebum content were compared between the two groups before and after 7,14,and 28 days of treatment.A generalized estimating equation model was used to analyze the time and group effects on skin lesion scores and DLQI scores.The inci-dence of adverse reactions during the treatment was compared between the two groups.Results The total clinical effective rate was significantly higher in the observation group than in the control group(95.00％vs.75.00％,x2=5.17,P=0.023).At all post-treatment time points,skin le-sion scores,inflammatory factor levels,and sebum content significantly decreased(P＜0.05),while DLQI scores significantly increased(P＜0.05)compared with baseline in both groups.The observation group demonstrated greater improvement than the control group on all indices(P＜0.05).The Generalized Estimating Equation analysis revealed significant interaction effects between time and group on both skin lesion scores and DLQI scores(P＜0.001).The total inci-dence of adverse reactions in the observation group was significantly lower than that in the control group(7.50％vs.25.00％,x2=4.50,P=0.034).Conclusions The combination of tradition-al Chinese medicine compound decoction and fire needle bloodletting is effective in reducing skin lesions,improving quality of life,lowering inflammatory levels,and decreasing sebum secretion in patients with cystic acne.Furthermore,it demonstrates a better safety profile compared to the combination of oral isotretinoin and fire needle bloodletting,suggesting its potential for clinical ap-plication.关键词
囊肿型痤疮/中药复方/火针/放血治疗Key words
cystic acne/traditional Chinese medicine compound decoction/fire needle/bloodletting therapy引用本文复制引用
焦建霞,赵艳君,赵玉,陈晓..自拟中药复方联合火针放血治疗囊肿型痤疮的临床疗效[J].皮肤性病诊疗学杂志,2026,33(4):262-270,9.基金项目
上海卫生健康委员会科技项目(2023KFY034) （2023KFY034）
