摘要
Abstract
Objective The surgical approaches for prostate cancer(PCa)and benign prostatic hyper-plasia(BPH)differ.PCa typically requires radical prostatectomy,while BPH is often managed with partial resection to alleviate symptoms.This study aimed to utilize quantitative dynamic contrast-enhanced magnetic resonance imaging(qDCE-MRI)to differentiate between PCa and BPH,thereby guiding the selection of surgical strategy.Methods Fifty-four patients with prostate nodules underwent conventional MRI and qDCE-MRI.The qDCE-MRI data were analyzed using the extended Tofts model to calculate quantitative and semi-quantitative parameters.The Mann-Whitney U test was employed to compare the differences in qDCE-MRI parameters between PCa and BPH groups.The predictive efficacy of each parameter was evaluated using receiver operating characteristic(ROC)curve analysis.The Spearman rank correlation test was used to analyze the linear correlation between quantitative parameters and PCa ISUP grade groups.Results Among the 54 patients,there were 31 cases of PCa and 23 cases of BPH.The PSA,Ktrans,Kep,Cmax,and Slopemax values were significantly higher in the PCa group than in the BPH group,while TTP was lower in the PCa group(P<0.05).The areas under the ROC curve for differentiating PCa from BPH ranged from 0.710 to 0.971.The sensitivity,specificity,and accuracy of PI-RADS score in discriminating PCa from BPH were 0.784,0.882 and 0.815,respectively.Slopemax showed a positive correlation with the PCa ISUP grade group(r=0.451,P=0.011),whereas other parameters did not exhibit significant correlations(P>0.05).Conclusion Both semi-quantitative and quantitative parameters derived from qDCE-MRI can effectively distinguish PCa from BPH,providing valuable guid-ance for selecting the appropriate surgical approach for prostate diseases.关键词
前列腺癌/前列腺增生/磁共振成像/动态增强Key words
prostatecancer/benignprostatichyperplasia/magneticresonanceimaging/dynamiccontrast-enhanced分类
医药卫生
