辽宁中医药大学学报2026，Vol.28Issue(6)：39-46,8.DOI:10.13194/j.issn.1673-842X.2026.06.007
中药多糖防治糖尿病视网膜病变机制研究
Research on the Study of the Mechanism of Traditional Chinese Medicine Polysaccharide Against Diabetic Retinopathy
摘要
Abstract
Diabetic retinopathy(DR)is one of the most severe microvascular complications of diabetes,progressing gradually and ultimately leading to blindness.Current clinical treatments such as laser photocoagulation and anti-vascular endothelial growth factor drugs demonstrate limited efficacy,accompanied by significant side effects,high recurrence rates,and inadequate neuroprotective effects.There is an urgent need to explore novel,safe,and effective therapeutic strategies.Traditional Chinese medicine(TCM)polysaccharides,as natural bioactive macromolecules,demonstrate unique advantages in DR prevention and treatment due to their multi-targeted action and low toxicity.Research indicates that TCM polysaccharides can delay DR progression and promote retinal functional repair through multiple mechanisms,including antioxidant and anti-inflammatory effects,inhibition of pyroptosis,suppression of abnormal neovascularization,and regulation of retinal ganglion cells.This paper systematically reviews the research progress of TCM polysaccharides in DR prevention and treatment,delves into their mechanisms of action and potential applications,and provides theoretical references for clinical management and novel drug development in DR.关键词
中药多糖/糖尿病视网膜病变/作用机制/研究进展Key words
traditional Chinese medicine polysaccharide/diabetic retinopathy/mechanism of action/research progress分类
医药卫生引用本文复制引用
王建盛,俞姣蓉,马小军,王志刚..中药多糖防治糖尿病视网膜病变机制研究[J].辽宁中医药大学学报,2026,28(6):39-46,8.基金项目
甘肃省自然科学基金项目(25JRRE013) （25JRRE013）
甘肃省级科技计划项目(22JR5RA611) （22JR5RA611）
甘肃省中医药管理局中医药防治重大疾病科研课题(GZKZD-2018-01) （GZKZD-2018-01）
甘肃省中医药管理局高水平重点课题(GZKZ-2024-39) （GZKZ-2024-39）
