辽宁中医药大学学报2026，Vol.28Issue(6)：47-53,后插1,8.DOI:10.13194/j.issn.1673-842X.2026.06.008
落新妇苷现代研究
Modern Research on Astilbin
摘要
Abstract
Astilbin(AST),a dihydroflavonoid present in traditional Chinese medicinal such as Tufuling(Smilax Glabra)and Huangqi(Astragali Radix).Recent studies have demonstrated that AST exhibits a broad spectrum of favorable pharmacological properties,including antioxidant,anti-inflammatory,immunomodulatory,glucose-regulating,neuroprotective,antitumor,and anti-hyperuricemic activities.It exhibits multi-pathway and multi-target characteristics in the treatment of various diseases,such as autoimmune,metabolic,and neurological disorders,as well as in cancer.These involve a range of signaling pathways,such as Nrf2/HO-1,MAPK/NF-κB/NLRP3,PI3K/AKT,TLR4/MyD88/NF-κB,JAK/STAT,P2Y6R/IL-8/CXCR2.Toxicological assessments indicate that AST possesses a favorable safety profile.However,pharmacokinetic studies highlight several challenges,including low oral bioavailability,rapid absorption and elimination,and instability under alkaline conditions.Among its metabolites,3'-O-methylastilbin serves as the primary active form,with 4'-O-methylastilbin as a secondary active derivative.To overcome these limitations,nanoformulations of AST have been developed,which prolong its half-life,improve absorption,and enhance bioavailability.By comprehensively reviewing literature from databases including CNKI,VIP,PubMed,and Web of Science,this article summarizes recent advances in the pharmacological activities,mechanisms,toxicology,pharmacokinetics,and nanoformulation strategies of AST.We anticipate that this systematic overview will facilitate further exploration of AST's therapeutic potential and support its clinical translation and drug development.关键词
落新妇苷/药理作用/机制/药代动力学/毒理学/纳米制剂Key words
astilbin/pharmacological effects/mechanisms/pharmacokinetics/toxicology/nanoformulations分类
医药卫生引用本文复制引用
徐晓涵,王欣竹,董晓旭,倪健,张慧中,常阿倩,彭胡麟玥,李诗曼,杨静雯,张可,王雯琪,李文静..落新妇苷现代研究[J].辽宁中医药大学学报,2026,28(6):47-53,后插1,8.基金项目
国家中医药管理局高水平建设学科项目(zyyzdxk-2023272) （zyyzdxk-2023272）
