国际眼科杂志2026，Vol.26Issue(6)：923-930,8.DOI:10.3980/j.issn.1672－5123.2026.6.01
电针干预对近视豚鼠脉络膜血流灌注及PI3K/Akt/mTOR－HIF－1α信号通路的影响
Electroacupuncture intervention on choroidal blood perfusion and the PI3K/Akt/mTOR－HIF－1α signaling pathway in myopic guinea pigs
摘要
Abstract
•AIM:To study the effects of electroacupuncture(EA)on choroidal blood flow,the phosphatidylinositol 3－ kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)－ hypoxia－ inducible factor 1－ alpha(HIF － 1α)signaling pathway,and ocular biological parameters in form deprivation myopia(FDM)－induced guinea pigs. •METHODS:The guinea pigs were randomly divided into four groups:blank control group;FDM group(subjected to form deprivation to simulate myopia development);FDM+EA group(subjected to form deprivation and treated with EA stimulation);FDM+sham acupuncture group(subjected to form deprivation and given EA stimulation).EA treatments were performed at the Taiyang(EX－HN5)acupoint for the FDM+EA group and at sham acupoints in the FDM+sham group.Measurements included refractive error,axial length(AL),corneal curvature,vitreous diameter,choroidal thickness,and vascular density of the choroid layer.Additionally,the expression levels of PI3K,Akt,mTOR,and HIF－1α mRNA in the sclera were detected. •RESULTS:Eight animals were included in each group.After 4 wk of treatment,the refractive error of the FDM+EA group was significantly reduced compared to the FDM group(P<0.001).The vascular density of the choroid in the FDM+EA group was significantly increased compared to the FDM group(P<0.001).The expression levels of PI3K,Akt,mTOR,and HIF－1α mRNA in the FDM+EA group were significantly reduced compared to the FDM group(P<0.001). •CONCLUSION:EA can improve the vascular density of choroid,antagonize the expression of PI3K/Akt/mTOR－ HIF －1α signaling pathway,effectively improve scleral hypoxia,reduce the diopter of myopic guinea pigs,and play a role in controlling the progression of myopia.关键词
近视/脉络膜血流灌注/PI3K/Akt/mTOR－HIF－1α信号通路/电针疗法Key words
myopia/choroidal blood perfusion/PI3K/Akt/mTOR-HIF-1α signaling pathway/electroacupuncture引用本文复制引用
秦汉,赵勇,浏梦,王雁,周顺,马鼎程,高云仙..电针干预对近视豚鼠脉络膜血流灌注及PI3K/Akt/mTOR－HIF－1α信号通路的影响[J].国际眼科杂志,2026,26(6):923-930,8.基金项目
General Program of the Natural Science Foundation of the Department of Science and Technology of Xinjiang Uygur Autonomous Region(No.2022D01C551) （No.2022D01C551）
Key Hospital-Level Research Project of the Fourth Affiliated Hospital of Xinjiang Medical University(No.ZYY2022ZD4) 新疆维吾尔自治区科学技术厅自然科学基金面上项目(No.2022D01C551) （No.ZYY2022ZD4）
新疆医科大学第四附属医院院级课题重点项目(No.ZYY2022ZD4) （No.ZYY2022ZD4）
