双调蛋白对眼部疾病调控作用的研究进展
Advances in the regulatory role of amphiregulin in ocular diseases
摘要
Abstract
•Amphiregulin(AREG)is a member of the epidermal growth factor family.As a key ligand of the epidermal growth factor receptor(EGFR),it can activate signaling pathways such as PI3K/Akt,ERK1/2,and STAT3,participating in biological processes such as cell proliferation,apoptosis inhibition,and inflammatory immune regulation.AREG is closely related to ocular diseases and plays an important role in corneal repair,improvement of retinal damage,and regulation of ocular axial length.This article summarizes the structure,distribution,and biological functions of AREG,focusing on its regulatory mechanisms in ophthalmic diseases:participating in dry eye disease associated with Sjögren’s syndrome by driving epithelial thickening and chronic inflammation;promoting corneal repair through an immune－epithelial coordination mechanism;abnormally activating the EGFR/PI3K pathway leading to lens opacity;regulating ocular axial length elongation through the retinal － scleral signal axis;modulating microglial polarization affecting the progression of diabetic retinopathy;and enhancing ocular tumor drug resistance through epigenetic modification.This article systematically reviews the molecular regulatory mechanisms of AREG in ophthalmic diseases,aiming to explore its potential for clinical application in ophthalmic diseases.关键词
双调蛋白/分子调控/干眼/角膜损伤/白内障/近视Key words
amphiregulin/molecular regulation/dry eye disease/corneal injury/cataract/myopia引用本文复制引用
陶云鹤,李玉娟,殷学伟,郭滨..双调蛋白对眼部疾病调控作用的研究进展[J].国际眼科杂志,2026,26(6):972-977,6.基金项目
国家自然科学基金项目(No.82405486) （No.82405486）
国家资助博士后研究人员计划(No.GZC20231505) （No.GZC20231505）
中国博士后科学基金(No.2024T170532) （No.2024T170532）
"泰山学者"项 目 专 项 基 金(No.tsqnz20231252) （No.tsqnz20231252）
山东省自然科学基金项目(No.ZR2020MH393,ZR2025QC1751,ZR2024QH003) （No.ZR2020MH393,ZR2025QC1751,ZR2024QH003）
山东省医药卫生科技项目(No.202307021591) （No.202307021591）
2024 山东省中医药科技项目基金项目(No.M20242001) （No.M20242001）
山东中医药大学临床科研专项(No.LCKY202432) （No.LCKY202432）
2024 年山东中医药大学第二批科学研究基金自然科学青年项目(No.KYZK2024Q15) National Natural Science Foundation of China(No.82405486) （No.KYZK2024Q15）
Postdoctoral Fellowship Program of China(No.GZC20231505) （No.GZC20231505）
China Postdoctoral Science Foundation(No.2024T170532) （No.2024T170532）
the Taishan Scholar Program of Shandong Province(No.tsqnz20231252) （No.tsqnz20231252）
Natural Science Foundation of Shandong Province(No.ZR2020MH393,ZR2025QC1751,ZR2024QH003) （No.ZR2020MH393,ZR2025QC1751,ZR2024QH003）
Shandong Provincial Medical and Health Science and Technology Project(No.202307021591) （No.202307021591）
the 2024 Shandong Province Traditional Chinese Medicine Science and Technology Project(No.M20242001) （No.M20242001）
the Clinical Scientific Research Special Project of Shandong University of Traditional Chinese Medicine(No.LCKY202432) （No.LCKY202432）
the Second Batch of 2024 Natural Science Youth Project of Shandong University of Traditional Chinese Medicine Scientific Research Fund(No.KYZK2024Q15) （No.KYZK2024Q15）
