视网膜神经血管单元的结构改变与功能失衡在青光眼发病中的作用
Structural alterations and functional imbalance of the retinal neurovascular unit in glaucoma pathogenesis
摘要
Abstract
•The neurovascular unit(NVU)is a sophisticated functional network comprising neurons,glial cells,and microvessels.NVU’s homeostatic imbalance plays a pivotal role in the pathogenesis of glaucoma.The disease mechanism can be attributed to disruptions within the interactive network among retinal ganglion cells,glial cells,and microvessels.Current research has increasingly focused on multi－target synergistic interventions aimed at restoring global NVU homeostasis.This provides novel avenues for neuroprotective strategies in glaucoma.This review summarizes the structural and functional alterations in these cellular components and discusses the interplay of multiple pathogenic mechanisms,including oxidative stress and inflammation,excitotoxicity,neurovascular uncoupling,dysregulation of intercellular communication,and impaired clearance of metabolic waste.关键词
青光眼/神经血管单元/视网膜神经节细胞/神经胶质细胞/微血管Key words
glaucoma/neurovascular unit/retinal ganglion cells/glial cells/microvessel引用本文复制引用
刘雨函,李强,王红义,宋琼涛..视网膜神经血管单元的结构改变与功能失衡在青光眼发病中的作用[J].国际眼科杂志,2026,26(6):990-995,6.基金项目
四川省科技计划项目(No.2025ZNSFSC0570,2025ZNSFSC0574) （No.2025ZNSFSC0570,2025ZNSFSC0574）
四川省中医药管理局科学技术研究专项课题项目(No.2023MS545) （No.2023MS545）
四川省大学生创新创业训练计划省级立项(No.S202510633032) （No.S202510633032）
成都市卫生健康委员会医学科研课题项目(No.2023029) （No.2023029）
成都中医药大学"杏林学者"学科人才科研提升计划(No.CCYB2025001) Sichuan Science and Technology Program(No.2025ZNSFSC0570,2025ZNSFSC0574) （No.CCYB2025001）
Scientific Research Project of Sichuan Administration of Traditional Chinese Medicine(No.2023MS545) （No.2023MS545）
Provincial Project of Sichuan College Students'Innovation and Entrepreneurship Training Program(No.S202510633032) （No.S202510633032）
Chengdu Municipal Health Commission Medical Research Project(No.2023029) （No.2023029）
Chengdu University of Traditional Chinese Medicine"Xinglin Scholars"Discipline Talent Research Enhancement Program(No.CCYB2025001) （No.CCYB2025001）
