农业环境科学学报2026，Vol.45Issue(4)：856-868,13.DOI:10.11654/jaes.2025-0651
噬菌体在畜禽养殖业防控耐药菌的应用研究进展
Research progress on the application of bacteriophages in controlling antibiotic-resistant bacteria in livestock and poultry farming industry
摘要
Abstract
This article systematically reviews the application and research progress of bacteriophages in intervening in the spread of resistance genes(ARGs)and the prevention and control of antibiotic-resistant bacteria(ARB)in livestock and poultry breeding environments.The paper pointed out that the livestock and poultry industry has become a key link in the breeding and spread of ARGs due to antibiotic abuse,and bacteriophages,especially lytic phages,can not only directly eliminate ARB by virtue of their specific cleavage mechanism,but also effectively inhibit the spread of ARGs by blocking the conjugation and other horizontal gene transfer(HGT)pathway.At the application level,this paper focused on the practical effects of bacteriophages in livestock and poultry manure treatment,animal product safety control,and internal infection prevention and control,including the advantages of specific phage,multivalent phage,and phage cocktail strategy.Although phage technology has shown potential as an alternative to antibiotics,it still faces multiple challenges such as host range limitations,environmental stability,economic costs of large-scale application,and potential ecological security risks.In the future,it is still necessary to promote the efficient and safe application of bacteriophage technology in animal husbandry through interdisciplinary cooperation and technology integration.关键词
噬菌体/裂解机制/耐药基因/水平基因转移/耐药菌防控/噬菌体鸡尾酒Key words
bacteriophage/lytic mechanism/antibiotic resistance genes(ARGs)/horizontal gene transfer(HGT)/control of antibiotic-resistant bacteria/phage cocktail分类
资源环境引用本文复制引用
刘芳,李海鹏,杨硕欣,彭锦星,张炜..噬菌体在畜禽养殖业防控耐药菌的应用研究进展[J].农业环境科学学报,2026,45(4):856-868,13.基金项目
中国农业科学院院级基本科研业务费(Y2025JC04) （Y2025JC04）
中国农业科学院科技创新工程重大科研任务(CAAS-ZDRW202306)Basic Scientific Research Fund at the Institute Level of the Chinese Academy of Agricultural Sciences(Y2025JC04) （CAAS-ZDRW202306）
Major Scientific Research Tasks of the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202306) （CAAS-ZDRW202306）
