青岛大学学报（自然科学版）2026，Vol.39Issue(1)：11-15,5.DOI:10.3969/j.issn.1006-1037.2026.01.03
OGG1调控心肌细胞增殖的功能研究
Functional Research on the Regulation of Cardiomyocyte Proliferation by OGG1
摘要
Abstract
To investigate the regulatory function of 8-oxoguanine DNA glycosylase 1(OGG1)on cardiomyocyte proliferation,si-OGG1 small interfering RNA(OGG1-si)and OGG1 overexpression adenovirus(OGG1-OE)were transfected to construct primary car-diomyocyte models with OGG1 knockdown and overexpression,respectively.The effi-ciency of knockdown and overexpression was detected by real-time quantitative PCR(qPCR),and the proliferation status of primary cardiomyocytes was evaluated by the ex-pression levels of proliferation markers(Ki67 and pH3).The results show that compared with the control group,the expression of proliferation markers Ki67 and pH3 is signifi-cantly decreased in the OGG1 knockdown group,while both of them significantly increase in the OGG1 overexpression group.This indicates that OGG1 has a crucial regulatory role in cardiomyocyte proliferation,and its overexpression can significantly promote cardio-myocyte proliferation,while knockdown inhibits cardiomyocyte proliferation.关键词
OGG1/心肌细胞增殖/Ki67/pH3Key words
OGG1/cardiomyocyte proliferation/Ki67/pH3分类
医药卫生引用本文复制引用
李博,王凯,方波,王昆..OGG1调控心肌细胞增殖的功能研究[J].青岛大学学报（自然科学版）,2026,39(1):11-15,5.基金项目
国家自然科学基金(批准号:82370291)资助. （批准号:82370291）
