器官移植2026，Vol.17Issue(3)：343-355,13.DOI:10.12464/j.issn.1674-7445.2026043
移植胰腺急性排斥反应临床诊疗指南
Clinical diagnosis and treatment guidelines for acute rejection of transplant pancreas
摘要
Abstract
Pancreas transplantation and simultaneous pancreas-kidney transplantation are the most effective treatments for diabetes,end-stage diabetic nephropathy,or diabetes combined with end-stage renal disease,which have achieved good therapeutic effects in the treatment of type 1 diabetes and some cases of type 2 diabetes.However,acute rejection of transplant pancreas remains one of the important factors affecting the survival of recipients and the transplant pancreas after pancreatic transplantation,and it is a key issue that needs to be urgently addressed.In order to further standardize the clinical diagnosis and treatment of acute rejection of transplant pancreas,experts in organ transplantation,transplantation pathology and immunology from the Branch of Organ Transplantation of Chinese Medical Association organized a joint effort to formulate the"Clinical diagnosis and treatment guidelines for acute rejection of transplant pancreas".The content covers 14 key clinical issues such as acute T-cell mediated rejection of transplant pancreas,acute antibody-mediated rejection,transplant pancreas biopsy,pathological standards,diagnosis and treatment methods.It summarizes 17 evidence-based recommendations.The guideline was developed based on the evidence grading and recommendation strength standards of the Oxford University Evidence-Based Medicine Center's 2009 edition,aiming to guide clinical practice through evidence-based methods,with the goal of improving the diagnosis and treatment level of acute rejection of transplant pancreas in China.关键词
胰腺移植/胰肾联合移植/移植胰腺急性排斥反应/急性抗体介导的排斥反应/急性T细胞介导的排斥反应/活组织检查/供者特异性抗体/Banff病理学诊断标准/混合性急性排斥反应分类
医药卫生引用本文复制引用
中华医学会器官移植学分会,马俊杰,方佳丽,陈知水,郭晖,周智广,苗芸,陈正,薛武军..移植胰腺急性排斥反应临床诊疗指南[J].器官移植,2026,17(3):343-355,13.基金项目
广东省自然科学基金(2022A1515012619) （2022A1515012619）
广州市临床高新技术项目(2023GX012) （2023GX012）
