器官移植2026，Vol.17Issue(3)：393-404,12.DOI:10.12464/j.issn.1674-7445.2025295
破局器官短缺:异种器官移植的关键临床应用技术突破与未来展望
Overcoming organ shortage:key clinical application technology breakthroughs and future prospects in xenogeneic organ transplantation
摘要
Abstract
The technology of xenogeneic organ transplantation,as one of the core strategies to address the current contradiction between the supply and demand of transplant organs,has achieved significant breakthroughs from basic research to clinical application driven by factors such as the innovation of gene modification technology,the injection of research capital and the expansion of clinical trials,especially with the first actual clinical application of a pig heart-to-human transplant.China is also at the forefront of this field.This article intends to summarize the international research trends of xenogeneic organ transplantation(including financial support,the evolution of research stages and global clinical trial cases),and analyze the evolution and optimization of xenogeneic transplantation immunosuppression schemes,as well as the breakthroughs and unresolved scientific issues in current key clinical application technologies.The aim is to comprehensively present the progress of this field from basic research to clinical transformation,and provide references for promoting the rapid development of China's xenogeneic transplantation technology and subsequent clinical transformation and research directions.关键词
异种移植/基因修饰猪/器官移植/临床研究/转化/免疫抑制/排斥反应/基因敲除Key words
Xenotransplantation/Genetically modified pig/Organ transplantation/Clinical research/Transformation/Immunosuppression/Rejection/Gene-knockout分类
医药卫生引用本文复制引用
陈军泽,张诚,简永远,董昆,马帅军,董淳强..破局器官短缺:异种器官移植的关键临床应用技术突破与未来展望[J].器官移植,2026,17(3):393-404,12.基金项目
广西自然科学基金项目(2023GXNSFBA026116) （2023GXNSFBA026116）
