燃料化学学报（中英文）2026，Vol.54Issue(5)：76-86,11.DOI:10.1016/S1872-5813(25)60626-8
仿纤维素酶固体酸催化剂结合域设计与研究进展
Design strategies and recent advances in cellulase-mimetic solid acid catalysts
摘要
Abstract
The dense crystalline structure and limited accessibility of cellulose severely hinder its efficient catalytic conversion.In response,biomimetic solid acid catalysts inspired by cellulase binding domains(CBDs)have emerged as a promising strategy to enhance cellulose hydrolysis by mimicking the substrate recognition and enrichment functions of natural enzymes.This review systematically summarizes recent advances in the design of CBD-mimetic solid acids based on four representative strategies:electrostatic anchoring,hydrophobic microenvironment engineering,spatial confinement and covalent lock-and-key mechanisms.The underlying principles of these approaches,including substrate-specific recognition,local concentration enhancement,and synergistic"adsorption-catalysis"effects,are critically discussed to elucidate their contributions in improving catalytic affinity,selectivity,and durability.Despite significant progress,challenges such as mass-transfer resistance and insufficient structural robustness remain in complex biomass conversion systems.Looking forward,the integration of sub-enzymatic materials,such as carbon quantum dots(CQDs),into biomimetic catalysts offers new opportunities to achieve efficient,recyclable and hierarchically organized catalytic systems,thereby providing a powerful route for the sustainable valorization of cellulose and other lignocellulosic resources.关键词
仿纤维素酶/固体酸催化剂/结合域/生物质转化Key words
biomimetic cellulase/solid acid catalyst/binding domain/biomass conversion分类
化学化工引用本文复制引用
王宥华,曹淑铃,龙天一,邹传军,程序,朱万斌,王洪亮..仿纤维素酶固体酸催化剂结合域设计与研究进展[J].燃料化学学报（中英文）,2026,54(5):76-86,11.基金项目
Supported by the National Key Research and Development Project of China(2023YFD1701504),the National Natural Science Foundation of China(22278422),the 2115 Talent Development Program of China Agricultural University Fund(1011-00109018),and the Beijing Innovation Team of the Modern Agricultural Industrial Technology System(BAIC08-2025-FQ02). （2023YFD1701504）
