日用化学工业（中英文）2026，Vol.56Issue(4)：449-462,14.DOI:10.3969/j.issn.2097-2806.2026.04.005
用于改善透明质酸透皮性能的阳离子脂质体递送系统的构建与评价
Construction of a cationic liposomal system for enhanced transdermal delivery of hyaluronic acid
王宇 1任爽 2杨素珍 2韩婷婷 2姬迎迎 2张子嘉 1张婉萍1
作者信息
- 1. 上海应用技术大学香料香精化妆品学部,上海 201418
- 2. 山东福瑞达生物股份有限公司,山东 济南 250000
- 折叠
摘要
Abstract
In this study,we developed a cationic liposome(OTAC-L)delivery system based on octadecyltrimethylammonium chloride(OTAC)to enhance the low percutaneous permeability of hyaluronic acid.OTAC-HA-L was successfully prepared,showing a particle size of(90.42±1.92)nm and a polydispersity index of 0.23±0.02.This was achieved through measurements of particle size,Zeta potential,and entrapment efficiency,as well as analysis film properties using a fluorescence probe and optimizing the OTAC amount in chicken embryo experiments.Transmission electron microscopy(TEM)confirmed that the liposomes had a regular spherical shape.Low-field NMR and isothermal calorimetry were employed to investigate the molecular movement of water and the thermodynamic parameters of the HA binding process,respectively,confirming the effective binding between HA and cationic liposomes.Fourier transform infrared spectroscopy(FT-IR)identified the characteristic absorption peak of HA,confirming successful loading of HA and interaction with the liposomes.In vitro permeation tests showed that OTAC-HA-L's permeation performance was significantly improved,with a cumulative permeation rate of 15％at 12 hours,which was 1.91 and 2.56 times higher than that of standard liposomes and aqueous HA,respectively.Additionally,the system demonstrated good stability under normal-,high-,and low-temperature conditions,making it a promising approach for deep HA delivery in skin care.关键词
透明质酸/阳离子脂质体/经皮渗透/包封率Key words
hyaluronic acid/cationic liposomes/percutaneous penetration/encapsulation efficiency分类
化学化工引用本文复制引用
王宇,任爽,杨素珍,韩婷婷,姬迎迎,张子嘉,张婉萍..用于改善透明质酸透皮性能的阳离子脂质体递送系统的构建与评价[J].日用化学工业（中英文）,2026,56(4):449-462,14.
