四川中医2026，Vol.44Issue(5)：47-52,6.DOI:10.26946/j.cnki.1000-3649.sczy.2510220005
归肾丸合逍遥散加减联合炔雌醇环丙孕酮片治疗肝郁肾虚型多囊卵巢综合征的回顾性研究
A retrospective study on the treatment of polycystic ovary syndrome of liver stagnation and kidney deficiency syndrome by combining modified Guishen Pill and Xiaoyao San combined with ethinylestradiol and cyproterone acetate tablet
摘要
Abstract
Objective To analyze the clinical effect of modified Guishen Pill and Xiaoyao San combined with ethinylestradiol and cyproterone acetate tablet in the treatment of polycystic ovary syndrome(PCOS)of liver stagnation and kidney deficiency syndrome.Methods A retrospective analysis was conducted on 97 patients with PCOS of liver stagnation and kidney deficiency syndrome who visited the gynecology outpatient clinic of The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University from March 2022 to March 2025.Based on different treatment regimens,they were divided into an observation group(48 cases)and a control group(49 cases).The observation group was treated with modified Guishen Pill and Xiaoyao San combined with ethinylestradiol and cyproterone acetate tablet,while the control group was treated with ethinylestradiol and cyproterone acetate tablet alone.Both groups were treated for three treatment courses.The TCM syndromic scores,follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),LH/FSH ratio levels,BMI index,menstrual cycle after stopping the medication were compared between the 2 groups before and after the treatment.The adverse reactions during the treatment were also recorded.Results After treatment,the observation group had lower TCM evidence scores,lower levels of LH,T,and LH/FSH ratio,and better recovery of the menstrual cycle after drug cessation,with statistically significant differences(P<0.05).The differences in FSH levels,BMI index,and the incidence of adverse reactions between the 2 groups after the treatment were not statistically significant(P>0.05).Conclusion The treatment of patients with PCOS with liver stagnation and kidney deficiency syndrome by combining modified Guishen Pill and Xiaoyao San combined with ethinylestradiol and cyproterone acetate tablet can effectively alleviate the clinical symptoms,improve the hormone level,promote the restoration of the menstrual cycle,and has a higher safety profile,which is better than that of the treatment of ethinylestradiol and cyproterone acetate tablet alone.关键词
归肾丸/逍遥散/炔雌醇环丙孕酮片/肝郁肾虚型/多囊卵巢综合征Key words
Guishen Pill/Xiaoyao San/Ethinylestradiol and cyproterone acetate tablet/Liver stagnation and kidney deficiency syndrome/Polycystic ovary syndrome分类
医药卫生引用本文复制引用
庞楠,杨雯闻,贺晓霞..归肾丸合逍遥散加减联合炔雌醇环丙孕酮片治疗肝郁肾虚型多囊卵巢综合征的回顾性研究[J].四川中医,2026,44(5):47-52,6.基金项目
四川省中医药管理局科学技术研究专项课题(2023MS155). （2023MS155）
