山西中医药大学学报2026，Vol.27Issue(4)：396-401,6.DOI:10.19763/j.cnki.2096-7403.2026.04.11
扶正安中汤联合奥沙利铂、氟尿嘧啶与亚叶酸钙方案治疗晚期胃癌的疗效观察
Observation on the efficacy of Fuzheng Anzhong Decoction combined with oxaliplatin,fluorouracil and leucovorin regimen in the treatment of advanced gastric cancer
摘要
Abstract
Objective:To observe the efficacy and safety of Fuzheng Anzhong Decoction combined with the oxaliplatin,fluorouracil and leucovorin(FOLFOX4)regimen in the treatment of advanced gastric cancer.Methods:Patients diagnosed with advanced gastric cancer in the Second Department of Oncology,the First Affiliated Hospital of Anhui University of Chinese Medicine from February 2024 to February 2025 were selected and randomly divided into a control group and a treatment group according to the random number table method,with 40 cases in each group.Patients in the control group received chemotherapy with the FOLFOX4 regimen,while patients in the treatment group received Fuzheng Anzhong Decoc-tion combined with the FOLFOX4 regimen.A treatment cycle was 21 days,and both groups completed three cycles.The clinical efficacy,Karnofsky Performance Status(KPS)score improvement,levels of tumor markers including carcinoembry-onic antigen(CEA),carbohydrate antigen 19-9(CA199)and carbohydrate antigen 72-4(CA724)before and after treat-ment,as well as the incidence of chemotherapy-related adverse reactions,were observed in both groups.Results:The clini-cal effective rate in the treatment group(87.5%)was significantly higher than that in the control group(67.5%),and the dif-ference was statistically significant(P<0.05).After treatment,the KPS score in the treatment group increased and was higher than that in the control group,with statistically significant difference(P<0.05,P<0.01).After treatment,the levels of tu-mor markers,including CEA,CA199 and CA724,in both groups were lower than those before treatment,and the improve-ment in tumor marker levels in the treatment group was superior to that in the control group,with statistically significant dif-ferences(P<0.05,P<0.01).The incidence rates of adverse reactions such as nausea and vomiting,decreased appetite,neuro-toxicity,leukopenia and diarrhea in the treatment group were lower than those in the control group,with statistically signifi-cant differences(P<0.05).Conclusion:Fuzheng Anzhong Decoction combined with the FOLFOX4 chemotherapy regimen can significantly enhance the therapeutic effect in patients with advanced gastric cancer,improve the KPS functional status score,reduce the concentrations of CEA,CA199 and CA724,and effectively reduce the occurrence of chemotherapy-related adverse reactions.关键词
晚期胃癌/扶正安中汤/化学治疗/FOLFOX4方案/临床效果Key words
advanced gastric cancer/Fuzheng Anzhong Decoction/chemotherapy/FOLFOX4 regimen/clinical efficacy分类
医药卫生引用本文复制引用
黄成龙,李崇慧,李梦茹,洪东方,赵慧慧..扶正安中汤联合奥沙利铂、氟尿嘧啶与亚叶酸钙方案治疗晚期胃癌的疗效观察[J].山西中医药大学学报,2026,27(4):396-401,6.基金项目
中国中医科学院科技创新工程(CI2023C012YL) （CI2023C012YL）
安徽省华佗中医药研究院科技重大专项"揭榜挂帅"(BZKZ2408) （BZKZ2408）
