山西中医药大学学报2026，Vol.27Issue(4)：414-418,423,6.DOI:10.19763/j.cnki.2096-7403.2026.01.15
益肾通络蠲疲汤治疗肾虚血瘀型癌因性疲乏临床疗效观察
Clinical observation on the efficacy of Yishen Tongluo Juanpi Decoction in treating cancer-related fatigue of kidney deficiency and blood stasis type
摘要
Abstract
Objective:To observe the clinical efficacy of Yishen Tongluo Juanpi Decoction in treating cancer-related fatigue(CRF)of kidney deficiency and blood stasis type.Methods:A total of 62 patients diagnosed with CRF in the first in-patient ward of Geriatrics Department and Oncology Department of Shanxi Provincial Integrated TCM and WM Hospital from March 2022 to August 2023 were selected and randomly divided into a control group and a study group using a random num-ber table,with 31 patients in each group.Patients in the control group received basic supportive treatment and symptomatic treatment,while patients in the study group were additionally administered Yishen Tongluo Juanpi Decoction on the basis of the control group's conventional treatment.Both groups were treated continuously for 3 months.A comprehensive evaluation method,including the Karnofsky Performance Status(KPS)score,Piper Fatigue Scale-Revised(PFS),and traditional Chinese medicine(TCM)syndrome scores,was adopted to test the patients'blood routine and liver and kidney functions,record ad-verse reactions,evaluate the safety of treatment,and comprehensively measure the therapeutic effect.Results:After treat-ment,the KPS scores of both groups improved,and the scores of the study group were higher than those of the control group,with statistically significant differences(P<0.05,P<0.01).The PFS scores(emotional,physical,cognitive,behavioral and total scores)and TCM syndrome scores of both groups decreased,and the scores of the study group were lower than those of the con-trol group,with statistically significant differences(P<0.05,P<0.01).The total effective rate of PFS score efficacy in the study group(83.87%)was significantly higher than that in the control group(41.93%),and the clinical cure rate(80.65%)was sig-nificantly higher than that in the control group(45.16%),with statistically significant differences(P<0.01).The blood routine and liver function indicators of patients in both groups were normal,and no adverse reactions occurred.Conclusion:Yishen Tongluo Juanpi Decoction demonstrates excellent efficacy and safety characteristics in the treatment of CRF,significantly al-leviating cancer-related fatigue and improving quality of life.This provides solid evidence for the clinical application of TCM in the field of CRF treatment,indicating its broad application potential and market value in this area.关键词
癌因性疲乏/益肾通络蠲疲汤/临床疗效观察Key words
CRF/Yishen Tongluo Juanpi Decoction/clinical efficacy observation分类
医药卫生引用本文复制引用
张莹莹,胡明丽,闫思思,王佳,王丽琴,贾文魁..益肾通络蠲疲汤治疗肾虚血瘀型癌因性疲乏临床疗效观察[J].山西中医药大学学报,2026,27(4):414-418,423,6.基金项目
山西省中医药管理局科研课题(2022ZYYC048) （2022ZYYC048）
