功能性消化不良患者痛敏腧穴的分布特征:一项病例对照研究
Distribution characteristics of somatic hyperalgesic acupoints in patients with functional dyspepsia:A case-control study
摘要
Abstract
Objective:To investigate the distribution characteristics of somatic hyperalgesic acupoints in patients with functional dyspepsia(FD),at the same time,the receiver operating characteristic(ROC)curve was used with healthy subjects to evaluate the distribution characteristics of hyperalgesic acupoints,and summa-rize the objective rule of acupoint hyperalgesia in patients with FD,aiming to provide objective evidence for the acupoint sensitization theory and the scientific basis for optimizing acupoint selection strategies of acupuncture for FD. Methods:A case-control study design was adopted with 40 patients with FD(FD group)and 38 healthy subjects(control group).The pressure pain threshold(PPT)and pain tolerance threshold(PTT)of acu-points on the abdomen,lumbar region,and lower limbs were measured by a pressure pain tester in both groups.The differences between the two groups were analyzed by statistical analysis,and the diagnostic efficacy of the sensitized acupoints was evaluated by ROC curve. Results:(1)The PPT in the FD group was lower than that in the control group at Tianshu(ST25)(Right:10.8 v.s.12.6,P=0.049)and Sanyinjiao(SP6)(Right:16.3 v.s.19.1,P=0.023),respectively.(2)Compared with the control group,the PTT in the FD group was lower at Zhongwan(CV12)(22.8 v.s.28.6,P=0.002),Tianshu(ST25)(Left:22.0 v.s.28.2,P=0.001.Right:22.6 v.s.27.3,P=0.016),Zusanli(ST36)(Left:21.3 v.s.26.6,P=0.007.Right:51.8 v.s.57.6,P=0.030),Shangjuxu(ST37)(Left:46.0 v.s.52.7,P=0.034.Right:46.6 v.s.58.4,P=0.009),Xiajuxu(ST39)(Left:44.9 v.s.54.1,P=0.021.Right:44.8 v.s.55.6,P=0.006),Yinlingquan(SP9)(Left:31.6 v.s.44.1,P=0.001.Right:33.5 v.s.42.8,P=0.003),Sanyinjiao(SP6)(Left:33.8 v.s.43.7,P=0.015.Right:33.6 v.s.41.5,P=0.013),and Xiaochangshu(BL27)(Left:41.9 v.s.52.8,P=0.007.Right:46.5 v.s.55.2,P=0.038)separately.(3)The diagnostic efficacy of left Yinlingquan(SP9)was the best(AUC=0.72,95％CI:0.61 to 0.83,P＜0.001),and the optimal cutoff value was＜44.Zhongwan(CV12)(AUC=0.68)on the abdomen and left Tianshu(ST25)(AUC=0.69)and right Xiajuxu(ST39)(AUC=0.67)on the lower limbs,and the left Xiaochangshu(BL27)(AUC=0.68)on the back all demonstrated the moderate diagnostic efficacy(AUC:0.67 to 0.69).Furthermore,except for the PPT at the right Tianshu(ST25)(P=0.17)and the PTT at the right Xiaochangshu(BL27)(P=0.05),the results of ROC analysis for all the other acupoints showed statistical significance(P＜0.05),suggesting that the sensitization of these acupoints may be valuable potentially for the diagnosis of FD. Conclusion:Patients with FD exhibit an objectively quantifiable hyperalgesic phenomenon,primarily char-acterized by a reduced PTT.The distribution of sensitized acupoints follows"horizontal distribution of acupoints"and"longitudinal division of meridians",which may provide a scientific basis for acupoint selection in acupuncture for FD.关键词
Functional dyspepsia(FD)/Hyperalgesia/Acupoint sensitization/ROC curve/Pressure algometerKey words
Functional dyspepsia(FD)/Hyperalgesia/Acupoint sensitization/ROC curve/Pressure algometer引用本文复制引用
高渊博,佘延芬,王雪松,李旭欣,向鹏安,焦竞谊,李炳贤,张俊茶,刘君,范玺胜..功能性消化不良患者痛敏腧穴的分布特征:一项病例对照研究[J].世界针灸杂志（英文版）,2026,36(2):178-188,11.基金项目
Supported by Key Research and Development Program of the Ministry of Science and Technology of the People's Republic of China:Study on Multi-dimensional Evaluation of Acupoint Sensiti-zation Characteristics and Mechanisms:2022YFC3500601 （）
Scientific Research Fund of the National Administration of Traditional Chi-nese Medicine:Development of an Active Health Auricular Acu-point Anti-inflammatory Therapeutic Instrument and Research on Its Anti-inflammatory Effects:GZY-KJS-2025-014 （）
Natural Science Foundation of Hebei Province:Study on Electroacupuncture at Gongsun(SP4)and Neiguan(PC6)Alleviating Ulcerative Colitis by Activating the Cholinergic Anti-inflammatory Pathway to Regulate NLRP3 Inflammasome:H2024423064.The study sponsors had no role in the design and conduct of the study （SP4）
collection,manage-ment,analysis,and interpretation of the data （）
preparation,re-view,or approval of the manuscript （）
and decision to submit the manuscript for publication. （）
