世界中医药2026，Vol.21Issue(3)：361-367,7.DOI:10.3969/j.issn.1673-7202.2026.03.001
密银花发挥不同功效的质量标志物预测研究
Prediction of Quality Markers for Different Efficacies of Lonicerae Japonicae Flos
摘要
Abstract
Lonicerae Japonicae Flos is the dry flower bud or early-blooming flower of Lonicera japonica Thunb.,a renowned Dao-di medicinal material.It contains diverse chemical constituents,primarily including organic acids,flavonoids,iridoids,and triterpe-noids.In this study,based on a comprehensive analysis of its chemical components and using chemical structure similarity,299 po-tential targets of Lonicerae Japonicae Flos were successfully predicted.Disease enrichment analysis identified the top 20 diseases highly related to Lonicerae Japonicae Flos,which were then mapped to its traditional Chinese medicine(TCM)indications.A net-work topology model was further applied to analyze and predict candidate quality markers(Q-markers)corresponding to different TCM diseases treated with Lonicerae Japonicae Flos.The results showed that luteolin,caffeic acid,and 7-epi-loganin were candidate Q-markers for treating carbuncle,furuncle,and erysipelas.Chlorogenic acid isomer combinations(chlorogenic acid,neochlorogenic acid,cryptochlorogenic acid,isochlorogenic acid B,and isochlorogenic acid C),luteolin,caffeic acid,luteoloside,and 7-epi-loganin were candidate Q-Markers for treating dysentery caused by noxious heat and wind-heat cold.Chlorogenic acid isomer combinations,luteolin,caffeic acid,and luteoloside were candidate Q-markers for treating pharyngitis,while luteoloside,hederagenin,caffeic acid,rutin,hyperin,and luteolin were candidate Q-markers for treating epidemic febrile disease.This study provides a theoretical basis for the precise quality control and further development of the Dao-di medicinal material Lonicerae Japonicae Flos.关键词
密银花/道地药材/质量标志物/质量控制/中医主治/化学结构相似性/网络拓扑模型Key words
Lonicerae Japonicae Flos/Dao-di herb/Quality marker/Quality control/Indications of traditional Chinese medicine/Chemical structure similarity/Network topological model分类
医药卫生引用本文复制引用
刘方舟,杨阳,李萌,杜昱,李逸豪,时宇静,邹佳忱,李园白..密银花发挥不同功效的质量标志物预测研究[J].世界中医药,2026,21(3):361-367,7.基金项目
国家自然科学基金青年科学基金项目(82204780) （82204780）
中国中医科学院优秀青年科技人才培养专项(ZZ15-YQ-052) （ZZ15-YQ-052）
中国中医科学院实验室项目(ZZSYS-1902-01CZ). （ZZSYS-1902-01CZ）
