世界中医药2026，Vol.21Issue(4)：573-578,589,7.DOI:10.3969/j.issn.1673-7202.2026.04.001
海藻玉壶汤加减海藻甘草对甲状腺肿大大鼠心肾及血脂的影响研究
Effects of Haizao Yuhu Decoction modified with Sargassum and Glycyrrhizae Radix et Rhizoma on Heart,Kidney,and Blood Lipids in Rats with Goiter
摘要
Abstract
Objective:To observe the effects of Sargassum(Sargassum pallidum)and Glycyrrhizae Radix et Rhizoma(Glycyrrhiza uralensis)in Haizao Yuhu Decoction(HYD),administered at twice the maximum dosage specified in the 2020 edition of Chinese Pharmacopoeia,on the heart,kidney,and blood lipids in goiter rats.Methods:A total of 128 male Wistar rats were randomly divid-ed into a blank group,model group,Euthyrox group,HYD group,HYD without Sargassum(HYD-H)group,HYD without Glycyrrhi-zae Radix et Rhizoma(HYD-G)group,HYD without both Sargassum and Glycyrrhizae Radix et Rhizoma(HYD-HG)group,and Sargassum plus Glycyrrhizae Radix et Rhizoma(HG)group.A goiter model was established using propylthiouracil(PTU).Euthyrox was used as the positive control,while the other groups were administered the corresponding decoctions by gavage.Samples were collected 12 h after the final administration.Serum levels of creatine kinase(CK),lactate dehydrogenase(LDH),blood urea nitro-gen(BUN),creatinine(Cr),uric acid(UA),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(ApoA1),and apolipoprotein B(ApoB)were measured.His-topathological changes in heart and kidney tissues were observed by hematoxylin-eosin(HE)staining.Results:Compared with the model group,serum BUN levels were increased in the HYD-H,HYD-HG,and HG groups(P＜0.05,P＜0.01).Serum Cr levels were significantly increased in the HYD-H group(P＜0.05).In the HYD-HG group,serum TG and ApoA1 levels were significantly increased(P＜0.01).In the Euthyrox group,serum ApoA1 and ApoB levels were significantly decreased(P＜0.05,P＜0.01).No significant histopathological changes in the heart and kidney tissues were observed in any treatment group under light microscopy.Conclusion:The modified HYD containing the Sargassum-Glycyrrhizae Radix et Rhizoma anti-drug combination did not produce obvious adverse effects on the heart and kidney of goiter rats and showed no significant improvement in dyslipidemia.关键词
海藻玉壶汤/海藻甘草/反药组合/甲状腺肿大/心肾功能/血脂/十八反/中药配伍Key words
Haizao Yuhu Decoction/Sargassum and Glycyrrhizae Radix et Rhizoma/Anti-drug combination/Goiter/Heart and kid-ney function/Blood lipids/Eighteen incompatibilities/Chinese medicine compatibility分类
医药卫生引用本文复制引用
董肖,修琳琳,钟赣生,田颐,刘晓庆,廖文勇,徐向楠,吴美晶,曹灿,柳海艳,陈绍红..海藻玉壶汤加减海藻甘草对甲状腺肿大大鼠心肾及血脂的影响研究[J].世界中医药,2026,21(4):573-578,589,7.基金项目
国家自然科学基金项目(82274118). （82274118）
