色谱2026，Vol.44Issue(5)：589-596,8.DOI:10.3724/SP.J.1123.2025.08009
药学综合创新实验:分子印迹聚合物制备及其在体内药物分析样品前处理中的应用
Integrated pharmaceutical innovation experiment:preparation of molecularly imprinted polymers and the application in sample pretreatment for in vivo drug analysis
摘要
Abstract
Under new pharmaceutical science initiatives and innovation training,we address complex biological sample analysis.A comprehensive pharmaceutical experiment was designed for this purpose.It integrates pharmaceutical analysis,polymer chemistry,and analytical chemistry.Advanced molecular imprinting technology(MIT)serves as the key tool.Cholic acid,a significant endogenous metabolite,is selected as the template.Cholic acid molecularly imprinted polymers(CA-MIPs)are synthesized via precipitation polymerization.Their structure is characterized using scanning electron microscopy(SEM)and Fourier transform infrared spectroscopy(FT-IR).The imprinting site and formation mechanism is elucidated.Adsorption performance is evaluated by high perfor-mance liquid chromatography(HPLC)and liquid chromatography-mass spectrometry(LC-MS).Selectivity and enrichment efficiency in plasma are assessed.The experiment covers material design,synthesis,and characterization.It also includes application performance evaluation.This demonstrates high-level innovation and challenge.The practice enhances students'innovative thinking and practical skills.It fosters social and professional responsibility.The project cultivates high-quality applied pharmaceutical talents.This represents a beneficial practice in holistic education.关键词
药学综合创新实验/分子印迹聚合物/生物样品前处理/结构表征/效能评价Key words
comprehensive pharmaceutical innovation experiment/molecularly imprinted poly-mers(MIPs)/biological sample pretreatment/structural characterization/efficiency evaluation分类
化学化工引用本文复制引用
姜媛媛,郭瑞玲,宋志花,刘宗亮,范雨彤,许卉..药学综合创新实验:分子印迹聚合物制备及其在体内药物分析样品前处理中的应用[J].色谱,2026,44(5):589-596,8.基金项目
山东省2024年人工智能赋能重点领域教学改革项目(D2024012) （D2024012）
山东省本科教学改革研究项目(M2023247) （M2023247）
山东省大学生创新创业训练计划项目(2025年度). Artificial Intelligence-Enabled Key Areas Teaching Reform Project of Shandong Province(No.D2024012) （2025年度）
Project of Undergraduate Teaching Reform Research of Shandong Province(No.M2023247) （No.M2023247）
College Students'Innovative Entrepreneurial Training Plan Program of Shandong Province(2025). （2025）
