陕西医学杂志2026，Vol.55Issue(5)：628-632,638,6.DOI:10.3969/j.issn.1000-7377.2026.05.009
血清sB7-H3、LTB4对急性牙髓炎患儿根管治疗期间急症发生的预测价值
Predictive value of serum sB7-H3 and LTB4 for endodontic interappointment emergencies in children with acute pulpitis
摘要
Abstract
Objective:To investigate the changes in serum levels of soluble B7-homolog 3(sB7-H3)and leukot-riene B4(LTB4)in children with acute pulpitis,and to evaluate their predictive value for endodontic interappoint-ment emergencies(EIAE).Methods:A total of 100 children with acute pulpitis were enrolled as the acute pulpitis group,and 96 healthy children were selected as the healthy control group.After root canal therapy,pain was evalua-ted using the Visual Analogue Scale(VAS).According to the occurrence of EIAE,the children were divided into a non-EIAE group(76 cases)and an EIAE group(24 cases).Serum levels of sB7-H3 and LTB4 were detected by en-zyme-linked immunosorbent assay kits.Spearman correlation analysis was used to assess the correlation between ser-um sB7-H3 and LTB4 levels and VAS scores.ROC curve analysis was performed to evaluate the predictive value of serum sB7-H3 and LTB4 for EIAE in children with acute pulpitis.DCA was applied to assess the clinical utility of the combined detection of serum sB7-H3 and LTB4 in predicting the risk of EIAE.Results:Serum levels of sB7-H3 and LTB4 in the acute pulpitis group were significantly higher than those in the healthy control group(all P＜0.05).The proportion of apical radiolucency on X-ray,duration of inflammation regression,and serum levels of sB7-H3 and LTB4 in the EIAE group were significantly higher than those in the non-EIAE group(all P＜0.05).Children with high serum levels of sB7-H3 and LTB4 had higher VAS scores than those with low levels(all P＜0.05).Serum sB7-H3 and LTB4 levels were positively correlated with VAS scores(all P＜0.05).The AUC of serum sB7-H3 and LTB4 alone for predicting EIAE was 0.805 and 0.842,respectively,and the combined AUC was 0.915,which was signifi-cantly higher than that of single detection(all P＜0.05).When the high-risk threshold ranged from 0.08 to 0.97,the net benefit rate of the combined prediction of EIAE risk by serum sB7-H3 and LTB4 was superior to that of single prediction.Conclusion:Serum levels of sB7-H3 and LTB4 are elevated in children with acute pulpitis and are associat-ed with VAS scores.The combination of sB7-H3 and LTB4 shows high predictive value for EIAE in these children.关键词
急性牙髓炎/可溶性B7同源体3/白三烯B4/根管治疗期间急症/预测价值Key words
Acute pulpitis/Soluble B7-homolog 3/Leukotriene B4/Endodontic interappointment emergencies/Predictive value分类
医药卫生引用本文复制引用
陈锦,李梦..血清sB7-H3、LTB4对急性牙髓炎患儿根管治疗期间急症发生的预测价值[J].陕西医学杂志,2026,55(5):628-632,638,6.基金项目
湖北省卫生健康委员会卫生健康科研立项项目(WJ2021F080) （WJ2021F080）
