现代中医药2026，Vol.46Issue(3)：33-38,6.DOI:10.13424/j.cnki.mtcm.2026.03.005
基于低氧诱导因子-1α防治肾间质纤维化研究进展
Research Progress on Therapeutic Approaches for Renal Interstitial Fibrosis and the Pathogenic Role of Hypoxia-Inducible Factor-1α
摘要
Abstract
Renal interstitial fibrosis(RIF)is the common pathway of chronic kidney disease(CKD),and end-stage renal disease(ESRD)is the end point.Hypoxia-inducible factor-1α(HIF-1α),a key nuclear transcription factor maintai-ning oxygen homeostasis,is activated under hypoxic conditions.The activated HIF-α influences RIF through multiple signa-ling pathways.The article reviews the biological characteristics of HIF-1α,the pathogenesis of RIF,the signaling pathways by which HIF-1α induces RIF,and potential therapeutic targets for RIF,it proposes that HIF-1α plays a crucial role in the process of renal interstitial fibrosis and suggests that targeting HIF-1α represents a promising therapeutic approach.The aim is to offer insights for preventing and treating RIF,improving renal function,and delaying the progression of CKD.关键词
低氧诱导因子-1α/肾间质纤维化/慢性肾脏病/发病机制/信号通路Key words
hypoxia inducible factor-1α/renal interstitial fibrosis/chronic kidney disease/pathogenesis/signaling pathway分类
医药卫生引用本文复制引用
高志强,崔海霞,崔玉彬,郭兆安,常玲玲..基于低氧诱导因子-1α防治肾间质纤维化研究进展[J].现代中医药,2026,46(3):33-38,6.基金项目
2024年潍坊市中医药管理局项目(WFZYY-2024-3-007) （WFZYY-2024-3-007）
