陕西中医药大学学报2026，Vol.49Issue(3)：26-32,7.DOI:10.13424/j.cnki.jsctcm.2026.03.003
中药调控TGF-β/Smad信号通路治疗糖尿病肾病炎症反应的研究进展
Research Progress of Chinese Medicine in Treating Inflammatory Response of Diabetic Nephropathy Based on the Regulation of TGF-β/Smad Signaling Pathway
摘要
Abstract
Diabetic nephropathy(DKD),one of the most severe microvascular complications of diabetes,can progress to end-stage renal disease if poorly managed,leading to the need for kidney replacement therapy,which poses significant physical harm and economic burden to patients.Inflammation is a key driver in the early stages of DKD and a critical mechanism leading to end-stage renal disease.Anti-inflammatory treatment is essential throughout the course of DKD.In recent years,the role of the transforming growth factor-β(TGF-β)/Smad signaling pathway in DKD has gained significant attention.The hyperglycemic state in DKD leads to abnormal activation of the TGF-β signaling pathway,triggering a cascade of inflammatory responses,extracellular matrix deposition,and promoting renal fibrosis.This signaling pathway is a key player in inflammation and fibrosis,driving renal damage.This article systematically reviews the mechanisms by which the TGF-β/Smad signaling pathway plays a role in the inflammatory response of DKD,and explores the research progress of TCM monomers and combinations,as well as their active ingredients,in treating DKD by regulating this signaling pathway,providing new ideas and theoretical foundations for TCM intervention and treatment of DKD.关键词
中药/TGF-β/Smad/糖尿病肾病/炎症反应Key words
Chinese medicine/TGF-β/Smad/diabetic nephropathy/inflammatory response分类
医药卫生引用本文复制引用
刘颖新,刘永惠,樊平..中药调控TGF-β/Smad信号通路治疗糖尿病肾病炎症反应的研究进展[J].陕西中医药大学学报,2026,49(3):26-32,7.基金项目
陕西省重点研发计划(2024SF-YBXM-502) （2024SF-YBXM-502）
