实用医学杂志2026，Vol.42Issue(10)：1737-1744,8.DOI:10.3969/j.issn.1006-5725.2026.10.007
LC+LTCBDE术治疗胆囊结石合并胆总管结石的炎症指标变化和短期疗效
The changes in immune-inflammatory indicators and short-term efficacy of the LC+LTCBDE surgery in the treatment of gallbladder stones combined with common bile duct stones
摘要
Abstract
Objective To explore the changes in immune-inflammatory indicators and the short-term thera-peutic effect of laparoscopic cholecystectomy(LC)+laparoscopic transcystic common bile duct exploration(LTCBDE)surgery for the treatment of gallbladder stones combined with common bile duct stones.Methods This study adopted a retrospective analysis method.A total of 803 patients with gallbladder stones and common bile duct stones who underwent surgical intervention at the Department of Hepatobiliary Surgery in the Affiliated Hospi-tal of Chengde Medical University from June 2021 to June 2025 were selected as the research subjects.The patients were grouped and compared according to different surgical methods.They were divided into Group A(treated with LTCBDE+LC surgery),consisting of 467 cases,and Group B(treated with LC+LCBDE+PDC surgery),with 336 cases.The perioperative and hospitalization data,liver function indicators,inflammation-related indicators,and the occurrence of complications were compared between the two groups of patients.Results The perioperative and hospitalization data of patients in Group A were significantly lower than those in Group B(P＜0.05).The lev-els of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and alkaline phosphatase(ALP)in Group A after surgery were significantly lower than those in Group B,while the level of serum albumin(ALB)was significantly higher in Group A than in Group B(P＜0.05).The levels of white blood cell count(WBC),C-reactive protein(CRP),and interleukin-6(IL-6)after surgery in Group A were significantly lower than those in Group B(P＜0.05).The incidence of postoperative complications was significantly higher in Group A than in Group B(11.56％vs.8.93％,P＜0.05).Conclusions Both the LTCBDE+LC surgery and the LC+LCBDE+PDC surgery demonstrate excellent short-term efficacy and safety when treating gallbladder stones combined with common bile duct stones.The LTCBDE+LC surgery is more suitable for patients with relatively simple conditions because of its advantages such as minimal trauma,rapid recovery,and preservation of biliary physiological func-tions.In contrast,the LC+LCBDE+PDC surgery is characterized by thorough stone removal and fewer long-term complications,rendering it more appropriate for the treatment of complex cases.关键词
胆囊结石/胆总管结石/腹腔镜胆囊切除术/胆总管探查术Key words
gallbladder stones/common bile duct stones/laparoscopic cholecystectomy/common bile duct exploration分类
医药卫生引用本文复制引用
唐冠杰,郑彬,李剑..LC+LTCBDE术治疗胆囊结石合并胆总管结石的炎症指标变化和短期疗效[J].实用医学杂志,2026,42(10):1737-1744,8.基金项目
河北省政府资助临床医学优秀人才培养项目资助(编号:ZF2026379) （编号:ZF2026379）
河北省医学科学研究课题计划项目资助(编号:20220420) （编号:20220420）
承德市科技计划自筹经费项目(编号:202204A046) （编号:202204A046）
承德市科学技术研究与发展计划项目基金资助(编号:201904A051) （编号:201904A051）
神经与肿瘤药物研发全国重点实验室项目基金资助(编号:SKLSIM-20250083) （编号:SKLSIM-20250083）
