实用医学杂志2026，Vol.42Issue(10)：1745-1751,7.DOI:10.3969/j.issn.1006-5725.2026.10.008
PON1-Q192R基因多态性与冠心病患者冠状动脉病变严重程度的相关性
Association of PON1-Q192R gene polymorphism with severity of coronary artery lesions in patients with coronary heart disease
摘要
Abstract
Objective To evaluate the association between the PON1-Q192R gene polymorphism and the severity of atherosclerotic lesions in coronary arteries among patients with coronary heart disease,and to analyze the influencing factors of the degree of coronary artery stenosis.Methods Patients diagnosed with coronary heart dis-ease at Northern Jiangsu People's Hospital between January 2024 and December 2024 were enrolled in this study.The PON1-Q192R genotype was detected using PCR-based pyrosequencing.Compare the baseline data of patients with distinct genotypes.Patients were categorized into groups based on the severity of coronary atherosclerosis ac-cording to the Gensini score system:mild stenosis group(＜20 points),moderate stenosis group(20-39 points),and severe stenosis group(≥40 points).The study examined the correlation between the PON1-Q192R gene poly-morphism and Gensini scores,and compared the distribution characteristics of different genotypes across coronary artery stenosis groups in patients with coronary heart disease.Univariate and multivariate logistic regression analy-ses were employed to investigate the associated factors influencing the degree of coronary artery stenosis.Results The median Gensini score showed that patients with the AG and AA genotypes were significantly higher than those with the GG genotype(P＜0.05).The proportion of patients with severe stenosis in the AG and AA genotypes was significantly higher than that in the GG genotype(P＜0.05).Comparing the distribution of the PON1-Q192R G/A alleles across different degrees of coronary artery stenosis also showed statistically significant differences(P＜0.05).Multivariate logistic regression analysis revealed that the AG genotype(OR=1.973,95％CI:1.078-3.610,P=0.027),AA genotype(OR=3.127,95％CI:1.245-7.853,P=0.015),hypertension(OR=2.234,95％CI:1.233-4.046,P=0.008),diabetes mellitus(OR=2.043,95％CI:1.064-3.920,P=0.032),and elevated LDL-C(OR=1.608,95％CI:1.157-2.234,P=0.005)were identified as risk factors for increased coronary artery steno-sis severity.Conclusions The PON1-Q192R gene polymorphism is significantly associated with an increased risk of coronary artery stenosis severity in patients with coronary heart disease.The PON 1-Q192R gene polymorphism can serve as an important indicator for predicting the severity of coronary artery stenosis in patients with coronary heart disease.关键词
PON1-Q192R基因/基因多态性/冠心病/冠状动脉狭窄程度/Gensini评分Key words
PON1-Q192R gene/genetic polymorphism/coronary heart disease/coronary artery stenosis severity/Gensini score分类
医药卫生引用本文复制引用
李颖萱,邵俊,冯倩,陈涛,刘佳..PON1-Q192R基因多态性与冠心病患者冠状动脉病变严重程度的相关性[J].实用医学杂志,2026,42(10):1745-1751,7.基金项目
江苏省研究型医院学会精益化用药科研基金项目(编号:JY202121) （编号:JY202121）
江苏省药学会—奥赛康医院药学科研项目(编号:A202545) （编号:A202545）
扬州市科技计划项目(编号:YZ2024091) （编号:YZ2024091）
