实用中医内科杂志2026，Vol.40Issue(5)：20-25,后插1-后插6,12.DOI:10.13729/j.issn.1671-7813.Z25010102
基于网络药理学及分子对接探讨二陈汤治疗2型糖尿病的作用机制
To Explore the Mechanism of Erchen Decoction(二陈汤)in Treating Type 2 Diabetes Mellitus based on Network Pharmacology and Molecular Docking
摘要
Abstract
Objective Based on network pharmacology and molecular docking to explore the therapeutic mechanism of Erchen Decoction(二陈汤)on type 2 diabetes mellitus.Methods the main active components and targets of Erchen decoction were screened from TCMSP database,and the disease targets related to type 2 diabetes mellitus were obtained from GeneCards and OMIM databases.To construct Erchen decoction and type 2 diabetes target Venn diagram,and obtain its common target.The pro-tein interaction network(PPI)of Erchen decoction in treating type 2 diabetes was generated by STRING database,and the core target was derived,cytoscape 3.10.2 was used to draw the network of"Active components-common targets-pathways-disease network".In combination with R 4.4.1 software,Gene Ontology and KEGG enrichment analysis were performed for the overlap-ping genes between erchen decoction and type 2 diabetes mellitus.Molecular docking techniques were used to further verify the interaction between drugs and targets.Results after screening,93 active components of Erchen decoction were identified success-fully,1492 target genes related to diseases,840 drug targets and 238 common targets of diseases and drugs,the core targets in-clude Tumor necrosis factors(TNF),protein kinase B1(AKT1),interleukin-1β(IL-1β),peroxisome proliferator-activa-ted receptor γ(PPARG)and silencing information regulator 1(SIRT1).Go enrichment showed that there were 1640 biological processes,90 molecular functions and 38 cells.KEGG enrichment analysis yielded 156 pathways.Molecular docking results showed that the main active components of Erchen decoction were naringin,(3s,6s)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone,Kaempferol,the docking with TNF,AKT1,IL-1β,PI3K and SIRT1 were good.Conclusion Erchen decoction may be related to the metabolism of the main active components,such as(3s,6s)-3-(benzyl)-6-(4-hydroxy-benzyl)Piperazine-2,5-quinone and Kaempferol modulate TNF,AKT1,IL-1β,PI3K and SIRT1 in the treatment of type 2 diabetes mellitus,to provide theoretical basis for clinical treatment and prevention of type 2 diabetes mellitus.关键词
二陈汤/2型糖尿病/网络药理学/分子对接Key words
Erchen Decoction(二陈汤)/type 2 diabetes mellitus/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
王志汕,林辰,钟佳男,王章林,肖绍坚,吴文思,陈淑娇..基于网络药理学及分子对接探讨二陈汤治疗2型糖尿病的作用机制[J].实用中医内科杂志,2026,40(5):20-25,后插1-后插6,12.基金项目
国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函[2023]85号) （国中医药人教函[2023]85号）
第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号) （国中医药人教函[2022]1号）
福建省自然科学基金计划项目(2020J01766) （2020J01766）
福建省糖脂疾病中医临床医学研究中心项目(闽社科[2023]3号) （闽社科[2023]3号）
福建省中医药科技项目资助计划项目(2025YBA033) （2025YBA033）
福建省自然科学基金计划项目(2025J01955) （2025J01955）
