实用中医内科杂志2026，Vol.40Issue(5)：29-32,4.DOI:10.13729/j.issn.1671-7813.Z25121205
基于多组学的中医药治疗冠心病作用机制研究进展
Research Progress on the Mechanisms of Traditional Chinese Medicine in the Treatment of Coronary Heart Disease Based on Multi-Omics
摘要
Abstract
Coronary heart disease(CHD)is a common cardiovascular condition characterized by symptoms such as chest tightness,chest pain,palpitations,and shortness of breath.Its pathogenesis is primarily associated with lipid metabolism disor-ders,inflammatory immune responses,endothelial dysfunction,oxidative stress,and thrombosis formation.Currently,treatment is mainly based on Western medicine;however,issues such as suboptimal drug efficacy and adverse reactions remain.Tradition-al Chinese medicine(TCM)has unique advantages in the prevention and treatment of CHD,demonstrating good safety and toler-ance.The integration of multi-omics technologies is gradually revealing the systems biology mechanisms by which TCM exerts therapeutic effects through the regulation of a"gene-protein-metabolite"multidimensional network.This article aims to review the latest advancements in the application of multi-omics technologies in the study of the mechanisms of TCM in the treatment of CHD,systematically elaborating on its characteristics of multi-component,multi-target,and integrated regulation,providing a theoretical basis for the modernization of TCM research and its clinical application.关键词
冠心病/中医药/多组学/作用机制/转录组学/蛋白质组学/代谢组学Key words
coronary heart disease/traditional Chinese medicine/multi-omics/mechanisms of action/transcriptomics/proteomics/metabolomics分类
医药卫生引用本文复制引用
盖巧稚,刘悦,叶晨,李珂珂,杨欢,徐月..基于多组学的中医药治疗冠心病作用机制研究进展[J].实用中医内科杂志,2026,40(5):29-32,4.基金项目
中国博士后科学基金项目(2021M691385) （2021M691385）
辽宁省科学技术基金项目项目(2023JH3/10200016) （2023JH3/10200016）
