时珍国医国药2026，Vol.37Issue(9)：1601-1607,7.DOI:10.70976/j.1008-0805.SZGYGY-2026-0901
肺部感染脓毒症主要证型与临床证据的相关性研究
Study on the correlation between main syndrome types of sepsis caused by lung infection and clinical evidence
摘要
Abstract
Objective To explore the distribution patterns of traditional Chinese medicine(TCM)syndrome types in patients with pul-monary infection-related sepsis and their correlation with clinical evidence,providing a basis for the objectification of TCM syndrome dif-ferentiation.Methods Based on a multicenter study involving 31 hospitals nationwide,a total of 1150 patients with pulmonary infection-related sepsis were included.Their general information,TCM syndrome types(toxin-heat syndrome,blood-stasis syndrome,fu-qi blockage syndrome,acute deficiency syndrome),and relevant clinical indicators such as inflammation,coagulation,and organ function were collected for statistical analysis.Results The distribution of syndrome types was predominantly Blood-Stasis Syndrome(28.26%)and toxin-heat syndrome(26.96%),followed by acute deficiency syndrome(25.04%)and fu-qi blockage syndrome(19.74%).Patients with acute deficiency syndrome had the highest 28-day mortality rate(52.43%).Each syndrome type showed characteristic dif-ferences in inflammatory markers,coagulation function,disease severity scores,oxygenation index,lactate levels,etc.(P<0.05).Logistic regression analysis further revealed independent influencing factors for each syndrome type,such as a positive correlation between acute deficiency syndrome and SOFA score,a positive correlation between toxin-heat syndrome and body temperature,and a positive correlation between blood-stasis syndrome and D-dimer levels.Conclusion Different TCM syndrome types of pulmonary infection-related sepsis are closely associated with specific clinical-pathological features,exhibiting distinct modern medical indicator profiles.TCM syndrome differentiation can provide important references for assessing disease severity,predicting prognosis,and guid-ing individualized treatment.关键词
肺部感染/脓毒症/证型/临床证据Key words
Pulmonary infection/Sepsis/Syndrome type/Clinical evidence分类
医药卫生引用本文复制引用
方邦江,齐文杰,吉紫乐,张文,周爽,宫晔,郭力恒,何健卓,李大欢,邓扬嘉..肺部感染脓毒症主要证型与临床证据的相关性研究[J].时珍国医国药,2026,37(9):1601-1607,7.基金项目
国家自然科学基金(82204890) （82204890）
国家自然科学基金(82374350) （82374350）
国家重点研发计划(2024YFC3505700 （）
2018YFC1705900) （）
中医药防治重症感染传承创新团队(ZYYCXTD-C-202403) （ZYYCXTD-C-202403）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023067) （zyyzdxk-2023067）
国家中医优势专科建设项目(2024YSZKZZYX006) （2024YSZKZZYX006）
中国科协青年人才托举工程(2023QNRC001) （2023QNRC001）
上海中医药大学第三期"学术荣誉计划"[中医药管理局第38号(2024)] （2024）
深圳市'医疗卫生三名工程'(SZZYSM202401018) （SZZYSM202401018）
中医药创新基金(CI2023C014LH) （CI2023C014LH）
