妇儿健康导刊2026，Vol.5Issue(8)：31-35,5.DOI:10.3969/j.issn.2097-115X.2026.08.007
早产儿有血流动力学意义的动脉导管未闭的影响因素分析
Analysis of influencing factors of hemodynamically significant patent ductus arteriosus in premature infants
摘要
Abstract
Objective To analyze the influencing factors of hemodynamically significant patent ductus arteriosus(hsPDA)in premature infants.Methods A total of 150 premature infants with patent ductus arteriosus admitted to Department of Neonatology,Shenzhen Maternity&Child Healthcare Hospital,Southern Medical University from January to December 2024 were selected.According to the results of cardiac ultrasound hemodynamic standards,they were divided into hsPDA group(n=98)and non-hsPDA group(n=52).The single factor and logistic regression were used to analyze the influencing factors of hsPDA.Results The single-factor analysis showed that gestational age,birth weight,sepsis,respiratory distress syndrome(RDS),platelet count(PLT),platelet distribution width(PCT),large platelet ratio(P-LCR),mean platelet volume(MPV),and platelet distribution width(PDW)were associated with hsPDA(P<0.05).The multivariate logistic regression analysis revealed that RDS,low PLT,low PCT,low P-LCR,high MPV,and high PDW were independent risk factors for hsPDA,while birth weight was a protective factor(P<0.05).Conclusion The occurrence of hsPDA in premature infants is closely related to low platelet function and RDS.Monitoring of early platelet parameters can assist in clinical intervention.关键词
早产儿/血流动力学意义的动脉导管未闭/血小板参数/影响因素Key words
Premature infant/Hemodynamically significant patent ductus arteriosus/Platelet parameter/Influencing factor分类
医药卫生引用本文复制引用
钟俊炎,黄美..早产儿有血流动力学意义的动脉导管未闭的影响因素分析[J].妇儿健康导刊,2026,5(8):31-35,5.基金项目
深圳市科技研发资金基础研究专项(自然科学基金)(JCYJ20220530155207016). （自然科学基金）
