陕西科技大学学报2026，Vol.44Issue(3)：92-98,7.
杜仲不同部位化学成分分析及其降脂活性研究
Study on analysis of chemical constituents of different parts of Eucommia ulmoides and their hypolipidemic activity
摘要
Abstract
To investigate the differences in chemical composition and content of different parts of Eucommia ulmoides and to explore their hypolipidemic activity of related extractions in vitro,the qualitative and quantitative analysis of the chemical constituents of different parts of Eucommia ulmoides were cconducted by UPLC-MS/MS and HPLC techniques.The re-sults showed that 81 compounds were found in Eucommia ulmoides barks,90 compounds in Eucommia ulmoides leaves,67 compounds in Eucommia uulmoides flowers and 53 com-pounds in Eucommia ulmoides seeds,and that Eucommia ulmoides bark and Eucommia ul-moides leaves exhibited the highest degree of similarity with 64 identical active compounds.The contents of kynurenine glycosides,pinoresinol diglucoside and quercetin were higher in Eucommia ulmoides bark than in other part,the contents of chlorogenic acid,catechin and ru-tin were higher in Eucommia ulmoides leaves than in other part.The contents of the chemical compounds of Eucommia ulmoides flowers and seeds were lower than those of Eucommia ul-moides bark and leaves.The in vitro bile acid salt binding rates of Eucommia ulmoides bark and leaves were 71.34％and 69.16％,and the inhibition rates of cholesterol were 78.47％and 76.18％,respectively,with no significant difference.This study clearly demonstrated the differences in the chemical composition of different parts of Eucommia ulmoides.Moreover,the lipid-lowering activity of Eucommia ulmoides leaves is comparable to that of Eucommia ulmoides bark,and Eucommia ulmoides leaves have great potential to replace or supplement Eucommia ulmoides bark in the pharmaceutical and food industries.关键词
杜仲皮/杜仲叶/降脂活性/UPLC-MS/MS技术Key words
Eucommia ulmoides bark/Eucommia ulmoides leaf/hypolipidemic activity/UP-LC-MS/MS technique分类
医药卫生引用本文复制引用
王洁,王慧,龙辉,翟鹏涛,陈雪峰..杜仲不同部位化学成分分析及其降脂活性研究[J].陕西科技大学学报,2026,44(3):92-98,7.基金项目
陕西省重点研发计划项目-重点产业创新链(群)-农业领域项目(2024NC-ZDCYL-04-14) （群）
陕西省重点研发计划项目-关键核心技术攻关-农业农村领域项目(2024NC2-GJHX-25) （2024NC2-GJHX-25）
陕西省重大科技创新专项-秦创原成果转化计划(西咸一体化计划)-高校院所"三项改革"成果转化项目-农业项目(L2023-ZDKJ-QCY-SXGG-GY-015) （西咸一体化计划）
陕西省西安市未央区科技计划项目(202416) （202416）
