新发传染病电子杂志2026，Vol.11Issue(2)：24-29,6.DOI:10.19871/j.cnki.xfcrbzz.2026.02.005
多重耐药菌医院感染分布特征与影响因素探究
Epidemiological characteristics and determinants of healthcare-associated infections due to multidrug-resistant organisms
摘要
Abstract
Objective To analyze the distribution characteristics and risk factors of multidrug-resistant organisms(MDRO)in hospital infections,and to provide a theoretical basis for the prevention and control of MDRO hospital infections.Method A total of 545 patients with hospital-acquired infections in Qingyang People's Hospital from January 1,2023 to December 31,2024 were selected as the research subjects.Among them,91 patients with MDRO infections confirmed by etiology were assigned to the case group.A 1:2 matched case-control study design was adopted,and 182 patients without MDRO infections were matched by age,gender,department,and admission time to form the control group.The chi-square test was used for univariate analysis,and the conditional Logistic regression model was applied to screen independent risk factors with matching factors(age,gender,department,and admission time)as stratification variables.Result A total of 545 cases of hospital-acquired infections were included,among which 91 cases were caused by multi-drug resistant bacteria,accounting for 16.69%(91/545).The main MDRO strains causing hospital-acquired infections were Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,and Staphylococcus aureus,with sputum specimens being the most common(37.36%).The high-incidence department was the comprehensive ICU(25.27%).Multivariate analysis showed that anemia(OR=2.803,95%CI:1.416-5.551),use of≥3 types of antibiotics(OR=2.397,95%CI:1.282-4.483),history of pulmonary infection(OR=2.569,95%CI:1.327-4.976),and previous ICU stay(OR=2.436,95%CI:1.242-4.779)were associated with an increased risk of MDRO hospital-acquired infections(P＜0.05).Conclusion In tertiary hospitals,MDRO infections are mainly caused by Gram-negative bacteria,with the comprehensive ICU being a high-risk area.Anemia,use of multiple types of antibiotics,history of pulmonary infection,and ICU stay are core risk factors.Stratified prevention and control strategies should be developed to effectively reduce the incidence of MDRO hospital-acquired infections.关键词
医院感染/多重耐药菌/病例对照研究Key words
Hospital infection/Multi-drug resistant bacteria/Case-control study分类
医药卫生引用本文复制引用
姚程洪,段凯悦,刘变叶,全富贵,张小亮,冯玉娟,姚子琰,李淑华,张浩军..多重耐药菌医院感染分布特征与影响因素探究[J].新发传染病电子杂志,2026,11(2):24-29,6.基金项目
1.甘肃省卫生健康行业科技创新重大项目(GSWSZD2025-14) （GSWSZD2025-14）
2.中央高校基本科研业务费专项资金项目(31920240079) （31920240079）
3.甘肃省卫生健康行业科研项目(GSWSKY2025-27) （GSWSKY2025-27）
