新发传染病电子杂志2026，Vol.11Issue(2)：35-40,6.DOI:10.19871/j.cnki.xfcrbzz.2026.02.007
更昔洛韦注射液联合重组人干扰素α-1b治疗呼吸道合胞病毒肺炎患儿的疗效研究
Study on the effect of ganciclovir injection combined with recombinant human interferon α-1b in the treatment of RSV pneumonia in children
摘要
Abstract
Objective To investigate the therapeutic efficacy of ganciclovir injection combined with recombinant human interferon alpha-1b on children with respiratory syncytial virus(RSV)pneumonia,providing a basis for clinical diagnosis and treatment of RSV pneumonia.Method 105 pediatric patients with RSV pneumonia(admitted from December 2021 to December 2023,aged 3-8 years)were randomly separated into combination group(35 cases),control group(35 cases),and regular group(35 cases)in Fu Xing Hospital,Capital Medical University.The regular group received conventional treatment,the control group was treated with recombinant human interferon α-1b,and the combination group was treated with ganciclovir injection combined with recombinant human interferon α-1b(including antipyretic,expectorant,antitussive,oxygen therapy and basic antiviral therapy).Result The total effective rate of the combination group(94.29%,33/35)was higher than that of the control group(68.57%,24/35)and regular group(57.14%,20/35)(all P＜0.05).The improvement of clinical indicators such as cough[(3.96±0.88)d],wheezing[(3.39±0.85)d],and dyspnea[(1.62±0.30)d]in the combination group was better than that in the control group[(6.35±1.17)d,(5.57±1.12)d,(3.27±0.69)d,respectively]and regular group[(7.59±1.34)d,(6.89±1.27)d,(4.62±0.84)d,respectively](all P＜0.05).After treatment,the levels of tumor necrosis factor alpha(TNF-α),procalcitonin(PCT),interleukin(IL)-10,CD8+,and immunoglobulin E(IgE)in both groups of children decreased,while CD4+increased.And the improvement amplitude of the combination group was higher than that of the control group and regular group(all P＜0.05).Conclusion The combination of ganciclovir injection and recombinant human interferon α-1b can improve the clinical symptoms,reduce inflammatory response and improve immune function in children with RSV pneumonia,the efficacy is certain,with definite efficacy and good safety.关键词
呼吸道合胞病毒肺炎/重组人干扰素α-1b/更昔洛韦注射液/疗效Key words
Respiratory syncytial virus pneumonia/Recombinant human interferon α-1b/Ganciclovir injection/Efficacy分类
医药卫生引用本文复制引用
何耀红,谭言国,陈谨,屈爽..更昔洛韦注射液联合重组人干扰素α-1b治疗呼吸道合胞病毒肺炎患儿的疗效研究[J].新发传染病电子杂志,2026,11(2):35-40,6.基金项目
北京健康教育协会工作委托项目(BJK.JY202204) （BJK.JY202204）
