摘要
Abstract
Objective To investigate the diagnostic value of serum transient receptor potential cation channel subfamily V member 4(TRPV4)combined with cystatin C(CysC)and lipoprotein-associated phospholipase A2(Lp-PLA2)for left ventricular hypertrophy(LVH)in patients with primary hypertension.Methods A total of 126 patients with primary hypertension who were admitted to the Department of Cardiovascular Medicine at Puren Hospital in Beijing from January 2022 to October 2024 were selected as the study subjects.Echocardiography was performed,and the left ventricular mass index(LVMI)was calculated.Based on LVMI,patients were divided into the LVH group(54 cases)and the non-LVH group(72 cases).General data and serum levels of TRPV4,CysC,and Lp-PLA2 were compared between the two groups.Multivariate Logistic regression analysis was used to identify influencing factors for LVH in primary hypertension patients.Pearson correlation analysis was employed to assess the relationships between the serum levels of TRPV4,CysC,Lp-PLA2 and LVMI in primary hypertension patients.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum TRPV4,CysC,and Lp-PLA2 for LVH in these patients.Results Compared to the non-LVH group,the LVH group exhibited significantly higher age,duration of hypertension,and serum levels of TRPV4,CysC,and Lp-PLA2(t=2.641,2.220,7.168,6.894,6.015,respectively;P<0.05).Multivariate Logistic regression analysis revealed that elevated serum levels of TRPV4,CysC,and Lp-PLA2 were risk factors for LVH in patients with primary hypertension(P<0.05).Serum TRPV4,CysC,and Lp-PLA2 levels showed positive correlations with LVMI(r=0.414,0.339,0.372;P<0.05).The area under the curve(AUC)of the combined diagnosis of LVH by serum TRPV4,CysC,and Lp-PLA2 was significantly higher than that of any individual marker(Z=5.812,6.256,6.091,respectively;P<0.05).Conclusion Elevated serum levels of TRPV4,CysC,and Lp-PLA2 are associated with LVH in patients with primary hypertension,and their combined detection has diagnostic value for LVH.关键词
原发性高血压/左心室肥厚/瞬时受体电位阳离子通道亚家族V成员4/胱抑素C/脂蛋白相关磷脂酶A2Key words
Primary hypertension/Left ventricular hypertrophy/Transient receptor potential cation channel subfamily V member 4/Cystatin C/Lipoprotein-associated phospholipase A2
