心脑血管病防治2026，Vol.26Issue(4)：17-21,45,6.DOI:10.3969/j.issn.1009-816x.2026.04.004
血清环状RNA ACAP2、环状RNA CDR1as水平与ST段抬高型心肌梗死患者病情严重程度及预后的关系
Serum levels of circular RNA ACAP2 and circular RNA CDR1as in relation to disease severity and prognosis of patients with ST-segment elevation myocardial infarction
李彦芳 1石雪 1宋利华 1赵丹华 1袁江永1
作者信息
- 1. 056002 邯郸,河北工程大学附属医院心血管内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between serum circular RNA(circRNA)ACAP2 and circRNA CDR1as levels and the severity and prognosis of patients with ST-segment elevation myocardial infarction(STEMI).Methods A total of 190 STEMI patients admitted to the Affiliated Hospital of Hebei University of Engineering from January 2021 to November 2023 were enrolled as the study subjects.They were divided into a mild group with 98 cases and a severe group with 92 cases based on Gensini scores.According to different prognostic outcomes,patients were classified into a good prognosis group with 138 cases and a poor prognosis group with 52 cases.The levels of circRNA ACAP2 and circRNA CDR1as were detected using qRT-PCR.Pearson correlation analysis was used to examine the correlation between serum levels of circRNA ACAP2 and circRNA CDR1as.Spearman correlation analysis was applied to analyze the correlation between circRNA ACAP2 and circRNA CDR1as levels and Gensini scores.Logistic regression analysis was conducted to identify influencing factors for the prognosis in STEMI patients.ROC curve analysis was performed to evaluate the predictive value of serum circRNA ACAP2 and circRNA CDR1as levels for the prognosis of STEMI patients.Results The serum levels of circRNA ACAP2 and circRNA CDR1as in the severe group were significantly higher than those in the mild group(t=17.535,27.748,respectively;P<0.05).Pearson correlation analysis showed a positive correlation between serum levels of circRNA ACAP2 and circRNA CDR1as(P<0.05),and Spearman correlation analysis indicated that both serum circRNA ACAP2 and circRNA CDR1as levels were positively correlated with Gensini scores(P<0.05).The differences in onset time,Killip classification,number of stents implanted,and serum levels of circRNA ACAP2 and circRNA CDR1as between the good and poor prognosis groups were statistically significant(t/χ2=10.153,7.154,15.882,29.436,33.294,respectively;P<0.05).Multivariate Logistic regression analysis results indicated that onset time,Killip classification,number of stents implanted,circRNA ACAP2,and circRNA CDR1as were influencing factors for the prognosis of STEMI patients(P<0.05).ROC curve analysis showed that the AUCs for predicting the prognosis of STEMI patients using serum circRNA ACAP2 and circRNA CDR1as levels were 0.843 and 0.818,respectively.The combined prediction of the two indicators yielded an AUC of 0.900,which was better than the prediction of either marker alone(Z=2.563,2.601;P<0.05).Conclusion The serum levels of circRNA ACAP2 and circRNA CDR1as in STEMI patients are closely related to the severity and prognosis of the disease.Their combined detection has certain clinical value for predicting patient prognosis.关键词
环状RNA ACAP2/环状RNA CDR1as/ST段抬高型心肌梗死/预后Key words
Circular RNA ACAP2/Circular RNA CDR1as/ST-segment elevation myocardial infarction/Prognosis引用本文复制引用
李彦芳,石雪,宋利华,赵丹华,袁江永..血清环状RNA ACAP2、环状RNA CDR1as水平与ST段抬高型心肌梗死患者病情严重程度及预后的关系[J].心脑血管病防治,2026,26(4):17-21,45,6.
