右江医学2026，Vol.54Issue(4)：313-319,7.DOI:10.3969/j.issn.1003-1383.2026.04.001
HIV合并结核分枝杆菌感染的生物标志物的诊断价值与研究进展
Diagnostic value and research progress of biomarkers for HIV co-infected with Mycobacterium tuberculosis
摘要
Abstract
Co-infection with human immunodeficiency virus(HIV)and Mycobacterium tuberculosis(MTB)poses a major global public health challenge.Particularly among immunocompromised patients,tuberculosis is one of the most common causes of death.HIV infection significantly alters the host's immune response to MTB,complicating the diagnosis of tuberculosis.Traditional diagnostic methods for tuberculosis,such as sputum smear and culture,show markedly reduced sensitivity in HIV-infected individuals,particular-ly among patients with low CD4 counts and those with extrapulmonary tuberculosis.Therefore,in recent years,researchers have been dedicated to identifying various types of biomarkers to improve the diagnostic accuracy of tuberculosis in HIV-infected individuals.This article focuses on the latest advancements in the diagnostic value of pathogen-based biomarkers and their limitations in HIV-positive populations,followed by an analysis of the application potential of novel host response-based biomarkers,and finally offers prospects for future directions such as multi-biomarker integration and artificial intelligence.关键词
人类免疫缺陷病毒/结核分枝杆菌/生物标志物/诊断价值Key words
human immunodeficiency virus(HIV)/Mycobacterium tuberculosis(MTB)/biomarkers/diagnostic value分类
医药卫生引用本文复制引用
周璐,李秋静,戴静毅..HIV合并结核分枝杆菌感染的生物标志物的诊断价值与研究进展[J].右江医学,2026,54(4):313-319,7.基金项目
昆明市卫生科技人才培养项目[2023-SW-(技)-28] （技）
昆明市科技计划项目(2023-1-NS-007) （2023-1-NS-007）
