右江医学2026，Vol.54Issue(4)：320-326,7.DOI:10.3969/j.issn.1003-1383.2026.04.002
斑秃免疫靶向治疗的研究进展
Research progress in immunotargeted therapy for alopecia areata
摘要
Abstract
Alopecia areata(AA)is a prevalent non-scarring alopecia driven primarily by immune dysregulation and genetic pre-disposition,but its precise pathogenesis remains incompletely understood.In recent years,with the in-depth exploration of the immuno-pathogenesis of AA(such as the collapse of hair follicle immune privilege,activation of the JAK-STAT signaling pathway,and Th cell imbalance),immunotargeted therapy has emerged as a research hotspot.This review systematically summarizes current progress in im-munotargeted therapy for AA,including JAK inhibitors,Th-related cytokines(e.g.,IFN-γ,IL-17),immune-checkpoint modulators,and emerging targets such as sphingosine-1-phosphate(S1P)receptor modulators and plasmacytoid dendritic cell(pDC)-depleting monoclonal antibodies.The efficacy and limitations of existing agents are discussed,and the prospects of precision-targeted combination therapy are envisioned.关键词
斑秃/免疫/靶向治疗/药物Key words
alopecia areata(AA)/immunity/targeted therapy/drug分类
医药卫生引用本文复制引用
国媛媛,周永芹,曹经江..斑秃免疫靶向治疗的研究进展[J].右江医学,2026,54(4):320-326,7.基金项目
肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)开发基金课题(2023KZL028) （三峡大学）
