疑难病杂志2026，Vol.25Issue(5)：535-540,6.DOI:10.3969/j.issn.1671-6450.2026.05.005
血清DGLA、IGFBP5在急性心肌梗死合并心源性休克患者中的表达及临床意义
Serum DGLA and IGFBP5 expression and their clinical significance in patients with acute myocardial infarction com-plicated by cardiogenic shock
摘要
Abstract
Objective To investigate the expression and clinical significance of serum dihomo-γ-linolenic acid(DGLA)and insulin-like growth factor binding protein 5(IGFBP5)in patients with acute myocardial infarction complicated by cardiogenic shock(AMICS).Methods A total of 184 AMICS patients admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2023 to May 2025 were prospectively enrolled as the AMICS group,along with 92 contem-poraneous patients with AMI alone as the control group(2∶1 ratio).Serum levels of DGLA and IGFBP5 were measured using enzyme-linked immunosorbent assay.The intra-aortic balloon pump in cardiogenic shock Ⅱ(IABP-SHOCK Ⅱ)score was calculated for AMICS patients,and correlations with serum DGLA and IGFBP5 were analyzed using Pearson correlation anal-ysis.Based on 30-day outcomes after admission,AMICS patients were divided into survival and death groups.Prognostic fac-tors and the predictive performance of serum DGLA and IGFBP5 were analyzed.Results Compared with AMI patients,AMICS patients had significantly lower serum DGLA levels and significantly higher IGFBP5 levels(both P＜0.05).Serum DGLAwas negatively correlated with IABP-SHOCK Ⅱ score,while IGFBP5 was positively correlated(r=-0.796,0.748,both P＜0.001).The 30-day mortality rate of AMICS patients was 39.67％(73/184).Compared with survivors,the death group showed significantly lower DGLA levels and significantly higher IGFBP5 levels(both P＜0.05).Increased IABP-SHOCK Ⅱscore(OR=2.064,95％CI:1.319-3.230,P=0.002),lactate(OR=1.392,95％CI:1.091-1.775,P=0.008),NT-proBNP(OR=1.024,95％CI:1.009-1.038,P=0.001),and IGFBP5(OR=1.004,95％CI:1.002-1.006,P=0.001)were independent risk factors for mortality,while elevated DGLA(OR=0.804,95％CI:0.725-0.892,P＜0.001)was an independent protective factor.The area under the ROC curve(AUC)for predicting mortality using serum DGLA,IGFBP5,and their combination were 0.786,0.801,and 0.870,respectively,with sensitivities of 0.753,0.807,and 0.785,and specificities of 0.670,0.626,and 0.835.The combined prediction outperformed either marker alone(both P＜0.05).Conclusion In AMICS patients,decreased serum DGLA and increased IGFBP5 levels are independently associated with poor prognosis.The combination of serum DGLA and IGFBP5 provides superior prognostic predictive value compared with either marker alone.关键词
急性心肌梗死/心源性休克/二高-γ-亚麻酸/胰岛素样生长因子结合蛋白5/预后Key words
Acute myocardial infarction/Cardiogenic shock/Dihomo-γ-linolenic acid/Insulin-like growth factor binding protein 5/Prognosis分类
医药卫生引用本文复制引用
热米拉·依布拉音,再努热木·艾则孜,哈斯达尔·米地里别克,巩亚楠,李艳红..血清DGLA、IGFBP5在急性心肌梗死合并心源性休克患者中的表达及临床意义[J].疑难病杂志,2026,25(5):535-540,6.基金项目
国家自然科学基金资助项目(82460099) National Natural Science Foundation of China(82460099) （82460099）
