疑难病杂志2026，Vol.25Issue(5)：552-556,5.DOI:10.3969/j.issn.1671-6450.2026.05.008
生长抑素联合卡络磺钠、兰索拉唑对老年PUB患者氧化应激指标及血清VEGF水平的影响
Effects of somatostatin combined with carbazochrome sodium sulfonate and lansoprazole on oxidative stress indicators and serum VEGF levels in elderly patients with PUB
摘要
Abstract
Objective To investigate the effects of somatostatin combined with carbazochrome sodium sulfonate and lansoprazole on oxidative stress indicators and serum vascular endothelial growth factor(VEGF)levels in elderly patients with peptic ulcer bleeding(PUB).Methods A total of 150 elderly PUB patients admitted to the Department of Digestive Medi-cine,Yongchuan Hospital of Chongqing Medical University from March 2021 to June 2024 were selected and divided into a control group and a treatment group using a random number table,with 75 cases in each group.The control group received carbazochrome sodium sulfonate and lansoprazole,while the treatment group received somatostatin combined with carbazo-chrome sodium sulfonate and lansoprazole.The therapeutic efficacy,coagulation indices[fibrinogen(Fib),thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)],oxidative stress indicators[superoxide dismutase(SOD),advanced oxidation protein products(AOPP),oxidized low-density lipoprotein(ox-LDL),malondialdehyde(MDA)],serum levels of peptide YY(PYY),VEGF,heat shock protein-70(HSP-70),hemostasis time,total hospital stay,and adverse reactions were compared between the two groups.Results The total effective rate was significantly higher in the treatment group(94.67％)than in the control group(80.00％)(x2=7.292,P=0.007).After 5 days of treatment,the levels of Fib,SOD,VEGF,and HSP-70 in the treatment group were significantly higher than those in the control group,while the levels of TT,PT,APTT,AOPP,ox-LDL,MDA,and PYY were significantly lower than those in the control group(t=5.938,7.756,6.661,7.528,7.566,9.657,10.186,4.882,6.238,8.941,12.220,all P＜0.001).The hemostasis time and total hospital stay were signifi-cantly shorter in the treatment group than in the control group(t=5.983,18.752,both P＜0.001).There was no statistically sig-nificant difference in the incidence of adverse reactions between the treatment group(14.67％)and the control group(9.33％)(P＞0.05).Conclusion The combination of somatostatin,carbazochrome sodium sulfonate,and lansoprazole demonstrates fa-vorable efficacy in treating elderly PUB patients.It can improve coagulation indices,reduce oxidative stress response,modulate serum levels of PYY,VEGF,and HSP-70,shorten the recovery process,and exhibits good drug safety.关键词
消化性溃疡出血/生长抑素/卡络磺钠/兰索拉唑/疗效/老年人Key words
Peptic ulcer bleeding/Somatostatin/Carbazochrome sodium sulfonate/Lansoprazole/Therapeutic effica-cy/Elderly分类
医药卫生引用本文复制引用
殷洪波,谭柯馨,龙玲,曾杰,何平..生长抑素联合卡络磺钠、兰索拉唑对老年PUB患者氧化应激指标及血清VEGF水平的影响[J].疑难病杂志,2026,25(5):552-556,5.基金项目
国家自然科学基金青年基金资助项目(82102250) （82102250）
重庆市科卫联合医学科研项目(CSTB2022NSCQ-MSX1440) Youth Program of the National Natural Science Foundation of China(82102250) （CSTB2022NSCQ-MSX1440）
Chongqing Joint Medical Research Project of Science and Health(CSTB2022NSCQ-MSX1440) （CSTB2022NSCQ-MSX1440）
