医学信息2026，Vol.39Issue(9)：61-65,5.DOI:10.3969/j.issn.1006-1959.2026.09.009
基于孟德尔随机化分析血液代谢物与脑出血的因果关系
Analysis of the Causal Relationship Between Blood Metabolites and Cerebral Hemorrhage Based on Mendelian Randomization
摘要
Abstract
Objective To explore the causal relationship between serum metabolites and intracerebral hemorrhage(ICH)by two-sample bidirectional Mendelian randomization(MR)analysis.Methods Genome-wide association study(GWAS)data of cerebral hemorrhage were obtained from public databases.A published GWAS containing 1400 metabolites was used as the exposure factor,and SNPs significantly related to the exposure factor were selected as the instrumental variable(IV).R software was used to analyze the causal relationship between serum metabolites and cerebral hemorrhage.The methods used include inverse variance weighting(IVW),MR-Eggeer regression and simple model method.The data results were analyzed such as heterogeneity,pleiotropy,sensitivity,etc.to verify the reliability of the results.The results were verified by reverse MR analysis.Results Metabolite"1-stearoyl-2-arachidonic acid-gpc(18:0/20:4)"(IVW:OR=0.888,95％CI:0.830-0.950,P<0.001)was negatively correlated with cerebral hemorrhage.Conclusion 1-Stearoyl-2-arachidonic acid-gpc(18:0/20:4)is a protective factor for cerebral hemorrhage.With the increase of this metabolite,the risk of cerebral hemorrhage decreases.This may provide a new reference for the pathogenesis,early prevention,clinical treatment and scientific research of cerebral hemorrhage.关键词
代谢产物/脑出血/孟德尔随机化/1-硬脂酰-2-花生四烯酰-gpc(18:0/20:4)/因果关系Key words
Metabolites/Cerebral hemorrhage/Mendel randomization/1-Stearoyl-2-arachidonic acid-gpc(18:0/20:4)/Causal relationship分类
医药卫生引用本文复制引用
覃露,翟阳,庞兴旺,王瀚,莫智珍,肖裕翰,黎海娜,池腾飞..基于孟德尔随机化分析血液代谢物与脑出血的因果关系[J].医学信息,2026,39(9):61-65,5.基金项目
1.广西自然科学基金(编号:2024GXNSFAA010252 （）
2022GXNSFBA035576) （）
2.中国博士后科学基金资助项目(编号:2024MD753922) （编号:2024MD753922）
3.2024 年广西青年岐黄学者培养项目(编号:GXQH202419) （编号:GXQH202419）
4.广西中医药适宜技术开发与推广项目(编号:GZSY22-73) （编号:GZSY22-73）
5.2025 年广西中医药适宜技术开发与推广项目(编号:GZSY2025086) （编号:GZSY2025086）
