中草药2026，Vol.57Issue(10)：3693-3699,7.DOI:10.7501/j.issn.0253-2670.2026.10.002
蒙古黄芪环阿屯烷型三萜类化合物及其肾损伤保护作用研究
Cycloartane triterpenoids from Astragalus membranaceus var.mongholicus and their renal protection against injury
摘要
Abstract
Objective To study cycloartane triterpenoids from Astragalus membranaceus var.mongholicus and their protective effects against cisplatin-induced renal injury.Methods The constituents were isolated from non-polysaccharide fractions of the aqueous extract of Astragalus membranaceus var.mongholicus by employing multiple chromatographic techniques including silica gel,Sephadex LH-20 and ODS.Their structures were identified based on the physicochemical properties as well as spectroscopic and spectrometric data.Their protective activities against renal injury were evaluated by detecting the cell viability of human renal proximal tubular epithelial(HK-2)cells injured by cisplatin.Results Four cycloartane triterpenoids were isolated from Astragalus membranaceus var.mongholicus and identified as 12-carboxy-20,24,25-trihydroxy-3-(β-D-xylopyranosyloxy)-6-(β-D-glucopyra-nosyloxy)-7(8)-ene-9,10-secocycloartane(1),astragaloside II(2),astragaloside Ⅳ(3)and astragaloside Ⅰ(4).Additionally,compounds 2 and 3 could significantly improve the decreased cell viability induced by cisplatin(P<0.05).Conclusion Compound 1 is a novel homocycloartane triterpenoid named homoastragaloside A,and compounds 2 and 3 exhibit protective effects against renal injury.关键词
蒙古黄芪/皂苷/环阿屯烷/高环黄芪皂苷A/肾保护活性Key words
Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao/saponins/cycloartane/homoastragaloside A/renal protective activity分类
医药卫生引用本文复制引用
张一鑫,范春雨,郭慧,马建彤,丁丽琴..蒙古黄芪环阿屯烷型三萜类化合物及其肾损伤保护作用研究[J].中草药,2026,57(10):3693-3699,7.基金项目
国家重点研发计划项目(2022YFC3501601) （2022YFC3501601）
