中国癌症杂志2026，Vol.36Issue(4)：404-411,8.DOI:10.19401/j.cnki.1007-3639.2026.04.009
胃癌潜在新型生物标志物临床探索研究进展与展望
Progress in clinical exploration of potential novel biomarkers in gastric cancer
摘要
Abstract
Gastric cancer is a highly prevalent malignancy worldwide.Challenges including difficult early diagnosis,substantial inter individual variability in treatment response,limited modalities for recurrence surveillance,and insufficient accuracy of prognostic assessment have long constrained improvements in patient survival.With advances in multi-omics technologies and liquid biopsy,gastric cancer biomarker research has entered a new era of precision and dynamic monitoring.This review systematically summarizes research progress across four critical domains:early screening,therapeutic efficacy prediction,recurrence surveillance,and prognostic evaluation.Circulating nucleic acids and metabolic biomarkers have enhanced the performance of noninvasive detection for early screening.Novel biomarkers provide evidence for individualized therapy in efficacy prediction.Molecular imaging enables precise detection of minimal residual disease in recurrence surveillance.Multi-omics integration has identified multiple molecular biomarkers with independent prognostic value.Current research demonstrates a trend toward integration,yet challenges persist,including biomarker heterogeneity,inefficient clinical translation,and inadequate standardization of detection methods.Future efforts should focus on establishing hierarchical biomarker systems,advancing prospective validation and interventional trials,developing accessible detection platforms,addressing special histological subtypes,and exploring combinatorial applications with emerging therapeutics to facilitate the translation of biomarkers from research discoveries to clinical practice,ultimately improving outcomes for gastric cancer patients.关键词
胃肿瘤/生物标记物/诊断/肿瘤复发/预后Key words
Stomach neoplasms/Biological markers/Diagnosis/Neoplasm recurrence/Prognosis分类
医药卫生引用本文复制引用
邢钰林,冯丹,湛先保..胃癌潜在新型生物标志物临床探索研究进展与展望[J].中国癌症杂志,2026,36(4):404-411,8.基金项目
国家自然科学基金(82072707) （82072707）
海军军医大学校级课题(2023MS023). National Natural Science Foundation of China(82503604).Research Project at the University Level of Naval Medical University(2023MS023). （2023MS023）
