中国病理生理杂志2026，Vol.42Issue(5)：1004-1010,7.DOI:10.3969/j.issn.1000-4718.2026.05.018
非编码RNA对周围神经损伤后程序性细胞死亡的调控作用及机制
Regulatory roles and mechanisms of noncoding RNAs in programmed cell death following peripheral nerve injury
摘要
Abstract
Peripheral nerve injury(PNI),primarily resulting from trauma,is frequently associated with symptoms including neuropathic pain,sensory disturbances,and muscle atrophy.Pathological alterations manifest not on-ly in injured nerves but also in dorsal root ganglia,spinal neurons,and glial cells.Programmed cell death(PCD),com-prising apoptosis,autophagy,pyroptosis,and ferroptosis,serves a crucial role in the initiation and progression of PNI.Thus,regulation of PCD represents a promising therapeutic strategy.Growing evidence indicates that noncoding RNAs(ncRNAs)affect the pathological processes of PNI through regulation of various PCD pathways.This review introduces the principal types of PCD associated with PNI and presents a comprehensive analysis of recent developments concerning the regulatory functions of ncRNAs in this process.The objective is to provide a substantive reference for developing ncRNA-based therapeutic approaches for PNI.关键词
程序性细胞死亡/非编码RNA/周围神经损伤Key words
programmed cell death/noncoding RNA/peripheral nerve injury分类
医药卫生引用本文复制引用
郭孝静,张立,吴珊红,王艳..非编码RNA对周围神经损伤后程序性细胞死亡的调控作用及机制[J].中国病理生理杂志,2026,42(5):1004-1010,7.基金项目
国家自然科学基金资助项目(No.82274623 （）
No.81973926) （）
