中国病理生理杂志2026，Vol.42Issue(5)：1011-1017,7.DOI:10.3969/j.issn.1000-4718.2026.05.019
腹侧被盖区介导的睡眠-觉醒神经环路的研究进展
Progress in sleep-wake neural circuit mediated by ventral tegmental area
摘要
Abstract
Sleep and wakefulness are vital physiological states of the human body,regulated by complex neu-ral circuits.The ventral tegmental area(VTA)in the midbrain is a dopaminergic wake-promoting nucleus,playing a key role in various processes like motivation,reward,anxiety,memory,addiction,and sleep.This review comprehensively examines recent research on how the VTA modulates the sleep-wake neural circuits.The analysis reveals that circuits in-fluencing wakefulness include VTA→nucleus accumbens(NAc)DA,VTA→medial prefrontal cortex(mPFC),VTA→NAc→PFC,dorsal raphe nuclei(DRN)GABA→VTA,ventral pallidum(VP)GABA→VTADA,VTAGlu→central amygdala(CeA),lateral hypothalamic area(LH)Hcrt→VTA,and basal forebrain(BF)Glu→VTA.For rapid eye movement sleep(REMS),the edunculopontine tegmental nucleus(PPT)→VTA pathway is crucial,while for non-REMS(NREMS),rostromedial tegmental nucleus(RMTg)GABA→VTADA is significant.Circuits related to circadian rhythm/sleep homeostasis involve su-prachiasmatic nucleus(SCN)→medial preoptic nucleus(MPON)→VTA,and habenula(Hb)→RMTg→VTA.Modula-tion of these circuits by the VTA offers promising avenues for understanding the neural mechanisms of sleep-wake cycles and developing interventions for sleep disorders.关键词
腹侧被盖区/睡眠/觉醒/神经环路Key words
ventral tegmental area/sleep/wake/neural circuit分类
医药卫生引用本文复制引用
窦婷婷,严兴科,马翠,张认真..腹侧被盖区介导的睡眠-觉醒神经环路的研究进展[J].中国病理生理杂志,2026,42(5):1011-1017,7.基金项目
甘肃中医药大学中医学一级学科"岐黄英才"导师专项基金项目(No.ZYXKBD-202409) （No.ZYXKBD-202409）
甘肃省联合科研基金一般项目(No.23JRRA1522) （No.23JRRA1522）
甘肃中医药大学科学研究与创新基金项目(No.2023KCYB-2) （No.2023KCYB-2）
甘肃省重点人才项目(甘组通字[2023]20号) （甘组通字[2023]20号）
